Because of natural exposure to wildfire smoke, nonhuman primates have provided an increased understanding of the long-term effects of smoke inhalation during infancy, shares Lisa Miller, University of California Davis (UC Davis). Dr. Miller also discusses with co-hosts Anne Chappelle and David Faulkner the importance of animal models in human health research and how nonhuman primates can be good models for vaccine testing, as was the case with COVID-19.   About the Guest Lisa A. Miller, PhD,...

With nonalcoholic fatty liver disease affecting nearly a third of the US population, Luma Melo, University of Pittsburgh, describes how mouse studies have shown that low-impact exercise can help reverse liver damage. Dr. Melo also shares with co-hosts Anne Chappelle and David Faulkner how research funding works in her native Brazil and the role of Brazilian women in toxicology.   About the Guest Luma Melo, PhD, University of Pittsburgh, started her scientific career in her native Brazil,...

While no longer national news, the Deepwater Horizon oil spill is still impacting the ecological health of the Gulf of Mexico and the livelihoods of the communities that rely upon the gulf’s aquatic life, as Robert “Joe” Griffitt of the University of Southern Mississippi reveals. Dr. Griffitt and co-hosts Anne Chappelle and David Faulkner discuss how ecotoxicology is both an applied and a basic science, as well as how scientific discovery is not always a linear process.   About the...

How human activity, chemical exposures, and environmental factors combine to contribute to wildlife population declines is at the forefront of the research by Dr. Caroline Moore and other teams at the San Diego Zoo Wildlife Alliance. Dr. Moore unravels the role of toxicology in wildlife conservation with co-hosts Anne Chappelle and David Faulkner.   About the Guest Caroline Moore, PhD, DVM, serves the San Diego Zoo Wildlife Alliance as a Scientist in Disease Investigations. In this role, she...

Even chocolate companies and wineries need toxicologists. Alexandria G. Lau, ToxStrategies Inc., has worked for both and shares her experiences with co-hosts Anne Chappelle and David Faulkner. They also discuss the research and development that goes into new food products and how toxicologists play a role in food safety. About the Guest Alexandria G. Lau, PhD, DABT, ToxStrategies Inc., is a toxicologist with a decade of experience in the food and beverage industry. She has extensive knowledge...

Biostatistics or data science for public health—whatever you choose to call it—informs understanding of the health and environmental impacts of exposures. Emory University’s Howard Chang discusses with co-hosts Anne Chappelle and David Faulkner the intricacies of interpreting data, the controversial P value, and the team science involved in studying public health challenges.   About the Guest Howard Chang, PhD, is a Professor in the Emory University Rollins School of Public Health Department...

With limited existing research on the effects of medications and exposures on lactation, Christina D. Chambers, University of California San Diego, shares work underway to better assess risks and benefits for mom and baby. Co-hosts Anne Chappelle and David Faulkner also discuss with Dr. Chambers the tricky roles of epidemiology and observational studies.   About the Guest Christina D. Chambers, PhD, MPH, is a Professor in the Department of Pediatrics and the Department of Family and...

Studying the effects of metals in whales and alligators, among other species, can offer immense insight into human health, John P. Wise Sr. tells Adverse Reactions co-hosts Anne Chappelle and David Faulkner. Dr. Wise also discusses research on chromosome instability and how you can help people everywhere make connections to the importance of environmental health.   About the Guest John P. Wise Sr., PhD, is head of the Wise Laboratory of Environmental and Genetic Toxicology and Professor of...

How do you set exposure limits to protect human health in a closed container floating in space? Valerie Ryder, a toxicologist at the NASA Johnson Space Center, takes co-hosts Anne Chappelle and David Faulkner into the small world of space toxicologists, where they also discuss research involving lunar dust, bone loss, and CO2. About the Guest Valerie Ryder, PhD, DABT, is a board-certified toxicologist with the NASA Johnson Space Center. She received a BA in chemistry with a minor in...

From vaping to wildfire smoke to pollutants such as diesel exhaust to airborne diseases, the lungs are the organ most exposed to our external environment, according to Ilona Jaspers of the University of North Carolina at Chapel Hill. Dr. Jaspers also introduces co-hosts Anne Chappelle and David Faulkner to convergence science, a new approach to interdisciplinary work meant to bring disparate experts together.   About the Guest Ilona Jaspers, PhD, is a Professor at the University of North...

With pre-print services, data sharing, open access, and the internet rapidly changing the journal publication landscape, Toxicological Sciences Editor-in-Chief Jeffrey M. Peters provides co-hosts Anne Chappelle and David Faulkner with perspective on how journals are adapting to the times. Dr. Peters also details how new training and guidance programs at ToxSci are aiming to enhance submissions and peer reviews.   About the Guest Jeffrey M. Peters, PhD, is a Distinguished Professor of...

Margaret “Meg” H. Whittaker, Managing Director and Chief Toxicologist of ToxServices LLC, outlines the similarities and differences between risk assessment, alternative assessments, and green chemistry. Co-hosts Anne Chappelle and David Faulkner also discover how alternative assessments can lead to safer and more sustainable products that protect animal, human, and environmental health and the importance of diversifying your portfolio when you’re a student or early career researcher.   About...

Ohio State University’s Darryl B. Hood reveals how a database with about 25,000 environmental factors and variables associated with the public health exposome may soon lead to major breakthroughs in addressing disparate public health outcomes in various communities. He also shares with co-hosts Anne Chappelle and David Faulkner his experiences from a lifetime of firsts—from being a plaintiff in Brown v. Board of Education to transitioning from an HBCU (historically black college and...

Epigenetics expert Dana C. Dolinoy of the University of Michigan School of Public Health illuminates how our nascent understanding of the epigenome is leading to breakthroughs in understanding the causes—and potential treatment—of some public health problems. Co-hosts Anne Chappelle and David Faulkner also talk with Dr. Dolinoy about the collaborative science happening in the field and what the future holds for epigenetics.   About the Guest Dana C. Dolinoy, PhD, received her PhD in genetics...

Retired National Institute of Environmental Health Sciences (NIEHS) Director and lifelong federal scientist Linda S. Birnbaum discusses the intersection of policy and science, as well as the effect of environmental exposures on public health, with co-hosts Anne Chappelle and David Faulkner. Dr. Birnbaum also shares her insights on how to be an effective leader and the importance of mentorship.    About the Guest Linda S. Birnbaum, PhD, DABT, ATS, is the former Director of the National...

Meet co-hosts Anne Chappelle and David Faulkner as they explore the origins of Adverse Reactions, how people are at the heart of all science, and why the science of toxicology is more relevant than ever. About Anne After graduating from the University of Delaware with a BS in biology in 1991, Anne Chappelle accidentally found her calling when she worked a gap year in an industrial toxicology laboratory. As it turned out, toxicology was the perfect marriage of protecting both human health...