Replicate cofounder and CEO Ben Firshman, and a16z partner Matt Bornstein, discuss the art of building products and companies that appeal to software developers. Ben was the creator of Docker Compose, and Replicate has a thriving community of developers hosting and fine-tuning their own models to power AI-based applications.

Longtime machine-learning researcher Pedro Domingos joins a16z General Partner Martin Casado to discuss the state of artificial intelligence, whether we're really on a path toward AGI, and the value of expressing unpopular opinions.

a16z General Partner Anjney Midha shares his perspective on the recent collection of Nobel Prizes awarded to AI researchers in both Physics and Chemistry. He talks through how early work on neural networks in the 1980s spurred continuous advancement in the field — even through the "AI winter" — which resulted in today's extremely useful AI technologies.

GPU access is like oxygen to AI startups: without it, they can't breathe. Here, a16z General Partner Anjney Midha explains the forces that lead to GPU shortages and price spikes, and how the firm mitigates these concerns for portfolio companies.

Bowen Peng and Jeffrey Quesnelle of Nous Research join a16z General Partner Anjney Midha to discuss their mission to keep open source AI research alive and activate the community of independent builders. The focus is on a recent project called DisTrO, which demonstrates it's possible to train AI models across the public internet much faster than previously thought possible.

Ambience cofounder and chief scientist Nikhil Buduma discusses the nuances of using AI models to build vertical applications (including in his space, health care), and why industry acumen is at least as important as technical expertise.

MotherDuck cofounder and CEO Jordan Tigani discusses DuckDB's spiking popularity as the era of big data wanes, as well as the applicability of SQL-based systems for AI workloads and the prospect of text-to-SQL for analyzing data.

Black Forest Labs founders Robin Rombach, Andreas Blattmann, and Patrick Esser sit down with a16z general partner Anjney Midha to discuss their journey from PhD researchers to Stability AI, and now to launching their own company that emphasizes open models.

a16z General Partner Vijay Pande walks us through the past two decades of applying software engineering to the life sciences — from the Folding@Home project that he launched, through AlphaFold and more. He also discusses the major opportunities for AI to transform medicine and health care, as well as some pitfalls that founders in that space need to watch out for.

PromptFoo founder and CEO Ian Webster discusses the importance of red-teaming for AI safety and security, and how bringing those capabilities to more organizations will lead to safer, more predictable generative AI applications.

Command Zero cofounder and CTO Dean de Beer discusses the benefits of training large language models on security data, as well as the myriad factors product teams need to consider when building on LLMs.

Anyscale cofounder and CEO Robert Nishihara discusses the challenges of training and running AI models at scale; how a focus on video models — and the huge amount of data involved — will change generative AI models and infrastructure; and the unique experience of launching a company out of the UC-Berkeley Sky Computing Lab (the successor to RISElab and AMPLab).

In this archive episode from 2015, a16z's Sonal Chokshi, Frank Chen, and Steven Sinofsky discuss DeepMind's breakthrough AlphaGo system, which mastered the ancient Chinese game Go and introduced the public to reinforcement learning.

Luma Chief Scientist Jiaming Song joins a16z General Partner Anjney MIdha to discuss Jiaming's esteemed career in video models, culminating thus far in Luma's recently released Dream Machine 3D model that shows abilities to reason about the world across a variety of aspects.

Design engineer Alasdair Monk shares his takes on how generative AI and LLMs are changing the way software developers — and the people building tools for them — do their jobs.

Inngest cofounder and CEO Tony Holdstock-Brown discusses the reality and complexity of running AI agents and other multistep AI workflows in production, and why developer tools for generative AI — and their founders — might look very similar to previous generations of these products.

Ideogram CEO Mohammad Norouzi shares his story of growing up in Iran, helping build influential text-to-image models at Google, and ultimately cofounding and running an AI startup. He breaks down the differences between transformer models and diffusion models, as well as the transition from researcher to startup CEO.

For this holiday weekend (in the United States) episode, we've stitched together two archived episodes from the a16z Podcast, both featuring General Partner Anjney Midha. In the first half, from December, he speaks with Mistral cofounder and CEO Arthur Mensch about the importance of open foundation models, as well as Mistral's approach to building them. In the second half (at 34:40), from February, he speaks with Stanford's Stefano Ermon about the state of the art in video models, including...

a16z's Guido Appenzeller and Matt Bornstein discuss the state of the generative AI market, about 18 months after it really kicked into high gear with the release of ChatGPT — everything from the emergence of powerful open source LLMs to the excitement around AI-generated music.

Founders Dean De Beer (Command Zero), Kevin Tian (Doppel), and Travis McPeak (Resourcely) share their thoughts on generative AI, as well as their experiences building with LLMs and dealing with LLM-based threats.

a16z's Zane Lackey and Joel de la Garza discuss the state of the cybersecurity market vis a vis generative AI, foundation models, and large language models — and explain why 2024 could be a watershed year for security teams.

Socket's Feross Aboukhadijeh joins a16z's Joel de la Garza to discuss the state of security for the open-source software supply chain, including how large language models can help both developers and security teams identify issues.

In this bonus episode from the a16z Podcast archives, set your wayback machine to the seemingly long ago summer of 2020, and enjoy a16z’s Sonal Chokshi and Frank Chen discussing GPT-3 and the advent of commercially available LLMs.

Pinecone Founder and CEO Edo Liberty discusses the promises, challenges, and opportunities for vector databases and retrieval augmented generation (RAG). He also shares insights and highlights from his decades-long career in machine learning.