How will life, the Universe, and everything end? This lecture looks at the evolution of our expanding Universe to project the prospects for life into the distant cosmological future. Recent observations show that we live in an infinite, accelerating universe. I will trace the evolution of the universe from the current age of stars into the future. The final state of the Universe will be cold, dark, and disordered, and ultimately inhospitable to life as we understand it or perhaps can imagine it. Recorded live on 2009 Dec 3 in Room 1005 Smith Laboratory on the Columbus campus of The Ohio State University.