Nephrology experts Jai Radhakrishnan, MD, and Dana Rizk, MD, delve into the complex disease of immunoglobulin A nephropathy (IgAN), addressing unmet treatment needs and novel frontiers of therapy. They discuss IgAN as a chronic disease, reviewing its pathophysiologic basis, morbidity and mortality including significant reductions in health-related quality of life, existing treatment options, and evolving new targeted therapies. The experts review treatment strategies, highlight case studies and share their experience improving long-term health outcomes.