Dr. Lisa Monteggia, a neuroscientist and Professor of Pharmacology at Vanderbilt University, shares her groundbreaking research on the anti-depressant effects of ketamine. In this episode, we discuss how ketamine affects the brain—she reveals the neural mechanisms it induces in the brain, how it works differently than other anti-depressant medicines (like SSRIs), and why dosing is so critical. We discuss Ketamine’s ability to induce plasticity in the brain and how that could revolutionize treatment for refractory depression.