Can cannabis be used as a sleep aid? Dr. Oludare Odumosu, a biochemist and CEO of Zelira Therapeutics, discusses a new cannabinoid-based formula designed to treat insomnia. We discuss how cannabinoids (such as CBN, THC, and CBD) might be able to offer therapeutic relief for the nearly 15% of adults suffering from chronic insomnia. He also discusses the results of the randomized double-blind placebo-controlled crossover trial to test the Zelira formula on patients with chronic insomnia.
Published 07/28/21
Dr. Kelan Thomas, PharmD, a psychiatric pharmacist, shares the latest clinical research on psilocybin (the active ingredient in "psychedelic" mushrooms") and other classic hallucinogens. We talk about the chemical profiles of psychedelics, the psychological benefits of these medicines, as well the potential risks and side effects. We also discuss preliminary research on micro-dosing and he shares some of the potential cardiovascular risks that might arise with this practice.
Published 05/17/21
Dr. Lisa Monteggia, a neuroscientist and Professor of Pharmacology at Vanderbilt University, shares her groundbreaking research on the anti-depressant effects of ketamine. In this episode, we discuss how ketamine affects the brain—she reveals the neural mechanisms it induces in the brain, how it works differently than other anti-depressant medicines (like SSRIs), and why dosing is so critical. We discuss Ketamine’s ability to induce plasticity in the brain and how that could revolutionize...
Published 03/09/21
Dr. Gul Dölen, a neuroscientist and Associate Professor at the Brain Science Institute at Johns Hopkins School of Medicine, discusses MDMA’s potential to reopen the critical period for social reward learning in animal research models. She shares how MDMA affects the brain’s capacity to process new social information and how long this enhanced neuroplasticity lingers. She also shares what happens to octopuses (typically anti-social creatures), when they are observed on MDMA, and the importance...
Published 01/28/21
Dr. Jonny Lisano, an exercise physiologist who specializes in the field of cannabis and exercise science, reveals patterns he has observed in his research between cannabis use and exercise performance. We discuss how cannabis use affects (and doesn’t affect) anaerobic fitness, pulmonary health, and the presence of C-Reactive proteins in your blood. We also discuss whether cannabis should be considered legitimate medicine for NFL players and why using cannabis before exercise might help you...
Published 12/09/20
Nick Jikomes, PhD, neuroscientist and the Director of Science & Innovation at Leafly, shares what he has learned analyzing crowd-sourced data from patients/consumers on cannabis strains and products. Dr. Jikomes reveals that there are only a handful of chemical subtypes among high-THC strains and he shares the three primary chemical profiles you might find at a dispensary. We also discuss the association between certain terpenes and cannabinoids, like Terpinolene & CBG.
Published 11/04/20
Psychiatrist Dr. Julie Holland, MD, reveals how psychedelic medicines, like cannabis, MDMA, and psilocybin can help us feel more connected to ourselves, our community, and the natural world. We discuss what happens to our brains when we take psychedelics, why we are hardwired for connection, and the difference between the recreational and medical models of using these substances. 
Published 10/14/20
Dr. Peter Grinspoon, MD shares his recovery story after facing after an addiction to prescription painkillers. We discuss some of the issues with current addiction therapy and rehabilitation programs and how we can improve the experience of recovery and reduce dependency on opiates by incorporating cannabis into addiction therapy.  
Published 09/28/20
Can cannabis improve your sex life? OB/GYN Dr. Genester Wilson-King reveals research indicating cannabis's potential as a natural aphrodisiac. We also talk about whether cannabis affects fertility, whether cannabis is safe to use during pregnancy, and using cannabis as medicine to treat endometriosis.
Published 09/09/20
Dr. Hutchinson reveals his emerging research that cannabidiol (CBD) can mitigate side effects of alcohol use disorder and opiate addition. We discuss how CBD could potentially reduce dependency on these substances, improve symptoms of these disorders, and play a larger role in addiction therapy. He also explains whether cannabis causes structural changes in the brain and shares his latest research about the effects of cannabis use among the elderly. 
Published 08/12/20
Dr.  Anna Schwabe, a cannabis geneticist, reveals why our sense of smell is a very reliable indicator when we’re trying to identify cannabis strains. We discuss cannabis epigenetics, i.e. why genetically identical cannabis plants may produce different levels of THC or CBD, even when they are grown in the same environment. And she gives some expert tips on shopping for cannabis, so you can have more insight into the phenotypes and true THC levels of the strains you’re buying. 
Published 07/30/20
Does cannabis have cytotoxic effects on cancer cells? In this episode, Professor Hinanit Koltai, a biologist and the Director of Cannabis Research at the Volcani Center in Israel, reveals what cannabis molecules has been most effective at killing and preventing the spread of colon cancer cell lines. We also discuss what cannabinoid or cannabis molecule formulations are showing promise in treating other types of cancer like lymphoma, as well as genetic disorders like Crohn’s disease.
Published 07/08/20
How are cannabis workers’ rights connected to the quality of medicine that patients consume?  Are dispensaries as socially responsible as their marketing indicates?Anthropologist Dr. Marty Otañez shares his research on cannabis workers’ rights and social responsibility and accountability among dispensaries and cultivation facilities. We talk about how we can build a more inclusive, diverse, and equitable industry and avoid the pitfalls of Big Tobacco.
Published 06/24/20
Dr. Reggie Gaudino, a Geneticist and IP expert, discusses the behind-the-scenes research at Steep Hill testing lab, where he was formerly the Chief Science Officer. “Cannabis will not kill you, but what grows on cannabis will,” he reveals, discussing a study on pathogens found in dispensary cannabis. We also discuss the development of the first cannabis DNA-based sex test, how to shop responsibly for cannabis, what makes a cannabis strain eligible for a legitimate patent, and why it’s...
Published 06/11/20
Dr. Potter shares his experience learning about psychotropic plants from indigenous shamans in Brazil and Mexico. We discuss the cross-cultural transfer of psychoactive plants (e.g. psychedelic mushrooms and ayahuasca) and how we can learn from indigenous tribes and use plant-based medicines to treat mental illness, like addiction and OCD. Dr. Potter also reveals his latest research at Leef Labs, where he is creating major and minor cannabinoid formulations for insomnia and pain relief.
Published 05/27/20
Dr. Mark Braunstein, MD shares his experience using medicinal cannabis to treat patients with trauma or mental health disorders, like depression, addiction, and anxiety. He reveals the benefits of using cannabis over pharmaceutical drugs and gives tips on how to incorporate cannabis into your mental wellness routine. We also dive into the latest research on ketamine and discuss what to expect if you book a psychedelic therapy session at his practice. 
Published 05/20/20
The old paradigm for medicine has been very black and white. Certain molecules are “good” and “medicinal,” while other molecules are “bad” and “criminal.” We saw this paradigm did not serve us with cannabis. It prevents scientific research and keeps potential medicine away from patients. In this upcoming season, we will continue to talk to scientists about cannabis as a plant and how it can be used as medicine, while expanding our conversational scope and covering a wider range of psychedelics.
Published 05/20/20
Suffering from chronic pain? Should you try cannabis? Dr. Paola Cubillos, MD, shares her insight from working with patients using cannabis to alleviate pain. She dispels some myths around THC and discusses this molecule’s effects on the body and brain. Hint: it’s not just the psychoactive sister of CBD. She recommends the best ways to consume cannabis and important factors to consider to determine if medical cannabis is right for you. We also talk about what conditions are best treated by...
Published 03/05/20
Published 03/05/20
Curious about biotech innovation in cannabis and hemp production? Jon Vaught, CEO of Front Range Biosciences, reveals how applying modern biotech practices to hemp/cannabis cultivation can create stronger, healthier plants and better medicine. We talk about Front Range’s clean stock program (which can prevent pathogens and contaminants from being introduced to hemp/cannabis) and how marker assisted breeding can produce plants designed to withstand climate conditions or ward off pests.
Published 01/21/20
If you’ve ever suffered from anxiety or stress and want to know how CBD can help, this is the episode for you. Neuroscientist Dr. Monika Fleshner reveals the results of her study testing the effects of cannabidiol on laboratory rats. We talk about how CBD can reduce the negative health consequences of stress and what we can learn from the animal research model that we can’t learn from observing humans.
Published 11/20/19
Have you ever tried two cannabis strains with the same name but completely different effects? Or wondered what differentiates an Indica and Sativa? In this episode, Dr. Daniela Vergara, an evolutionary biologist researching Cannabis genomics, reveals how biology and understanding the cannabis genome could be beneficial to breeding efforts and to creating cannabis medicine that is more consistent and effective for patients. If you don’t know what a genome is, keep listening. We'll break it down. 
Published 11/06/19
How does cannabis affect our cognitive functioning? How soon can we drive safely after consuming? Does cannabis affect men and women differently? Dr. Cinnamon Bidwell, a psychologist and co-founder of the CU change mobile lab, reveals her findings from a number of research studies that she has done in a mobile pharmacology/psychology lab. 
Published 10/29/19
How does cannabis affect our cognitive functioning? How soon can we drive safely after consuming? Does cannabis affect men and women differently? Dr. Cinnamon Bidwell, a psychologist and co-founder of the CU change mobile lab, reveals her findings from a number of research studies that she has done in a mobile pharmacology/psychology lab. 
Published 10/17/19
Dr. Catherine Jacobson, a neuroscientist, shares her journey to find quality CBD medicine for her son, Ben, who was born with epilepsy. From processing black market cannabis in her garage to launching an initial access trial for Epidiolex (pharmaceutical-grade CBD), Dr. Jacobson speaks candidly about her efforts to make cannabis medicine accessible. We talk about how cannabis affects the brain, the social stigma around CBD and THC, and the future of cannabinoid-based medicine. 
Published 10/17/19