Neal Brennan has upped the artistic ante in stand-up comedy. In Netflix specials like "3 Mics and Blocks" he’s explored loneliness, isolation, and the mental health fallout of growing up the youngest of 10 in a Catholic family with an extremely unwell father. In the process he’s made some of the great mysteries of family pain and inner turmoil more tolerable. And—he’s a fan of our podcast, because in his search for relief, he’s tripped through the land of psychedelics, where conspirituality can sour the active ingredients. Neal joins us today to talk about his weird journey through the plant medicine scene, to wonder whether emotional and spiritual healing makes him funnier, and to answer our questions about how today’s comics are dealing—or not—with their supersized role as political pundits. His new special is called Crazy Good. Learn more about your ad choices. Visit megaphone.fm/adchoices