By the end of this lecture the attendee will be able to: 1. Appreciate the spectrum of available cellular therapies 2. Describe the biology of cell therapies in the context of critical illness 3. Discuss the current evidence base for cell therapies and be aware of important ongoing trials 4. Understand the challenges associated with delivering cell therapy in the clinic

By the end of this lecture the attendee will be able to: 1. understand the frequency and types of critical illness that arises across patients with cancer 2. recognize the unique types of critical illness that can arise as a consequence of novel cancer therapies 3. understand the changes across prognosis across critically ill patients with cancer 4. develop an approach to goals of care conversations across patients with cancer

By the end of this lecture the attendee will be able to: 1. Identify haemoglobin transfusion thresholds in adult intensive care practice 2. Discuss the limitations of the available evidence 3. Discuss the role of therapies to reduce the occurrence and severity of anaemia in ICU 4. Describe the association between anaemia, iron deficiency and adverse outcomes in ICU

By the end of this lecture the attendee will be able to: 1. Understand the role of the skeletal system in relation to critical illness and multi-organ dysfunction 2. Appreciate the significance of hyper-resorptive bone loss during critical illness and the longer-term consequences of this 3. Know about the potential strategies to recognise and mitigate bone loss 4. Acquire a brief knowledge of the pharmacology of drugs used to prevent bone loss

By the end of this lecture, the attendee will be able to: 1. Understand the definition of Acute Liver Failure. 2. Review evidence for neuroprotective strategies. 3. Review the potential benefits of extracorporeal support including continuous renal replacement therapy. 4. Review challenges in prognostication and the potential role for novel biomarkers.

By the end of this lecture, the attendee will be able to: 1. Understand the ethical pitfalls surrounding the diagnosis of death in the context of organ donation. 2. Understand the basis of some of the main legal challenges to the concept of brain death. 3. Recognise the ethical limitations of the ‘Dead Donor Rule’ in organ donation. 4. Understand that the main considerations for families contemplating organ donation are prognosis and consent rather than the presence of death.

By the end of this lecture the attendee will be able to: 1. Describe 3 validated tools for measuring pain in the critically ill population. 2. Identify the most painful procedures commonly performed in the ICU. 3. Describe some risk factors for pain in the ICU. 4. Understand some of the long-term effects of chronic pain after critical illness. 5 Prescribe a multi-modal treatment plan for a critically ill patient.

By the end of this lecture, the attendee will be able to: 1. Profile the ‘real time’ evolution and integration of research into clinical practice. 2. Understand challenges to the “gold standard” RCT threatened by political pressure, pre-print servers, news media sensationalism and public concerns for immediacy. 3. Reinforce ‘good clinical practice’ standards with evolving knowledge to strike an appropriate therapeutic balance.

A summary of steroid use in sepsis and the latest evidence-based recommendations.

By the end of this lecture, the attendee will be able to: 1. Understand the current practice patterns for use of opioids in the ICU. 2. Understand the pros and cons of multi-modal analgesia as an alternative to opioids in the ICU. 3. Know the rates of long-term use for opioids after critical illness. 4. Identify risk factors for long-term use of opioids after critical illness.

By the end of this lecture, the attendee will be able to: 1. Understand the EEG setup. 2. Understand the basic technical aspects of EEG. 3. Learn to recognize common ICU EEG patterns. 4. Understand how EEG is used in the diagnosis and prognosis of numerous conditions.

By the end of this lecture, the attendee will be able to: 1. Understand the integration of cardiovascular physiology and pharmacology of drugs used to support the failing circulation. 2. Recognise the limitations of derived and surrogate indices in determining haemodynamic function. 3. Understand the role and application of endogenous catecholamine infusions in supporting the failing circulation. 4. Understand the limitations of the use of synthetic vasoactive drugs in critically ill...

By the end of this lecture, the attendee will be able to: 1. Understand the risks and benefits associated with the use of proton pump inhibitors for stress ulcer prophylaxis in the ICU. 2. Describe the design and key findings of the PEPTIC trial. 3. Develop a practical understanding of when to use stress prophylaxis based on available evidence. 4. List key patient subgroups where data suggest that using proton pump inhibitors for stress ulcer prophylaxis may increase mortality risk.

By the end of this lecture, the attendee will be able to: 1. Understand the different study methods used in critical care. 2. Appreciate the strengths and weaknesses of different research methods. 3. Discuss appropriate methods of analysis. 4. Understand when study results should or should not affect your practice.

By the end of this lecture, the attendee will be able to: 1. Recognise situations that may lead to diagnostic mistakes in the management of the critically ill patient. 2. Recognise situations that may lead to management mistakes in the management of the critically ill patient. 3. Respond with appropriate diagnostic decisions in specific critically ill scenarios. 4. Respond with appropriate therapeutic decisions in specific critically ill scenarios.

By the end of this lecture, the attendee will be able to: 1. Outline the clinical presentation of autoimmune encephalitis, as it applies to critical care. 2. Describe diagnostic and therapeutic approaches to autoimmune encephalitis. 3. Describe unique issues encountered in the critically injured autoimmune encephalitis patient. 4. Outline the outcomes both locally and globally of patients with autoimmune encephalitis in the ICU.

By the end of this lecture, the attendee will be able to: 1. Better understand the epidemiology of sepsis. 2. Challenge the current dogma. 3. Question the proportion of attributable and avoidable deaths. 4. Appreciate that many patients do not have infection but rather sepsis mimics. 5. Place management in context.

By the end of this lecture, the attendee will be able to: 1. Describe the normal bacterial flora of the gut in health and critical illness. 2. Trace changing views of the role of the gut in disease. 3. Describe the role of the gut as a reservoir of endotoxin. 4. Discuss gut-directed strategies to reduce the burden of critical illness.

By the end of this lecture, the attendee will be able to: 1. Describe the potential biological basis for harm associated with liberal oxygen therapy in mechanically ventilated adults who are critically ill. 2. Explain the findings of the ICU-ROX trial. 3. Summarise evidence from other randomised controlled trials evaluating oxygen therapy in the ICU. 4. Outline the key design features of the Mega-ROX trial.

By the end of this lecture, the attendee will be able to: 1. Describe the global picture of inflammation. 2. Know the different components of inflammation and immune factors. 3. Understand the kinetic of the immune response after the hit. 4. Being able to propose some important routine and more specific biomarkers to become classic in the near future. 5. Understand the potential targets for immune modulation.

By the end of this lecture, the attendee will be able to: 1. Recognise medical errors most commonly present in the ICU. 2. Respond promptly to adverse events by performing root cause analyses and applying evidence-based risk reduction strategies. 3. Understand the importance of systematic investigations by multidisciplinary teams in respons eto serious adverse events in the ICU.