Design of experiments was born as a result of an unlikely, but true anecdote: a lady claimed before R.A. Fisher that she was able to ascertain whether milk was poured before or after tea in her cuppa. Fisher devised a study to verify her claim and, in turn, this gave birth to Experimental Design. Agricultural experiments formed the core around which the theory evolved in its origins in the 1930s. The theory of Design of Experiments has since blossomed into many different approaches, ranging from optimal designs for dynamical models in pharmacokynetic studies, and designs for industrial...