Welcome to another exciting episode of Resiliency Radio with Dr. Jill Carnahan! In this episode, Dr. Jill Carnahan sits down with the renowned Dr. Nathan Bryan to discuss the fascinating connection between beauty and health, with a specific focus on the role of Nitric Oxide (NO). Nitric Oxide, or NO, is a crucial molecule that plays a vital role in our overall well-being. It is not only responsible for regulating blood pressure and promoting cardiovascular health but also acts as a powerful anti-inflammatory and neurotransmitter. Hope you enjoy this week’s episode!  I’m beyond grateful for your support! 👇🏼 Key Points Nitric oxide (NO) is a crucial signaling molecule in the body, especially for endothelial health.  ✅ The endothelium, which lines the inner surface of blood vessels, plays a vital role in regulating vascular tone, blood flow, and vascular homeostasis. Here are some key physiological purposes of nitric oxide in endothelial health that I discuss with Dr. Nathan Bryan ✅ Vasodilation: Nitric oxide is a potent vasodilator, meaning it relaxes the smooth muscle cells in blood vessel walls, leading to the dilation of blood vessels. This dilation increases blood flow and reduces blood pressure, promoting cardiovascular health. ✅ Blood Pressure Regulation: By causing vasodilation, nitric oxide helps to regulate blood pressure. It counters the vasoconstrictive effects of other molecules such as endothelin-1, angiotensin II, and thromboxane, thus maintaining vascular tone and blood pressure within healthy ranges. ✅ Prevention of Platelet Aggregation: Nitric oxide inhibits platelet aggregation and adhesion to the endothelium, thus preventing thrombosis and maintaining blood fluidity. This antiplatelet effect reduces the risk of clot formation and cardiovascular events like heart attacks and strokes. ✅ Anti-inflammatory Effects: Nitric oxide exerts anti-inflammatory effects within the endothelium by inhibiting the expression of adhesion molecules and cytokines involved in the inflammatory response. By reducing inflammation, NO helps to preserve endothelial function and integrity. ✅ Endothelial Cell Survival: Nitric oxide promotes the survival of endothelial cells by activating survival pathways and inhibiting apoptosis (programmed cell death). This ensures the maintenance of a healthy endothelial layer and supports overall vascular health. ✅ Antioxidant Properties: NO acts as an antioxidant within the endothelium, scavenging reactive oxygen species (ROS) and preventing oxidative stress-induced damage to endothelial cells. This antioxidant activity helps to maintain endothelial function and integrity. ✅ Neurotransmission: In addition to its effects on blood vessels, nitric oxide serves as a neurotransmitter in the nervous system, including the central and peripheral nervous systems. It plays a role in neuronal communication, synaptic plasticity, and neurotransmitter release. Overall, nitric oxide plays a multifaceted role in endothelial health, contributing to vascular relaxation, blood pressure regulation, antiplatelet activity, anti-inflammatory effects, endothelial cell survival, antioxidant defense, and neurotransmission. Dr. Nathan Bryan Dr. Bryan is an international expert in nitric biochemistry and molecular medicine. His more than 20 years in academic research led to many seminal discoveries and has resulted in dozens of issued U.S. and International patents. Products from his innovations are the most successful nitric oxide products in the market and responsible for hundreds of millions of dollars in revenue around the globe and have improved patient care for more than a decade. https://drnathansbryan.com/ https://n1o1.com/ https://www.youtube.com/channel/UCtftGy8e0r9DO8ActcyGi4w