Metabolism of xenobiotics Detoxification: Biochemistry:U.Satyanarayana
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Description
The term detoxication or detoxificafion refers to fhe series of biochemical reactions occurring in the body to convert the foreign (often toxic) compounds to non-toxic or less toxic, and more easily excretable forms.Knowledge of the metabolism ol xenobiotics is essenfial for the understanding of toxicology, pharmacology and drug addiction. The bodV possesses the capabilitg to get rid of the foreign subsfonces by conuerting them into more easily excretoble forms. Detoxit'ication is not necessarily associated with the conuersion ol toxic into non-toxic compounds. For instance, methonol is metabolized to a more toxic formaldehyde. Detoxification primarily occurs in the liuer through one or more of the reactions, namely oxidation, reduction, hydrolysis and conjugation. British antilewisite (BAL), o compound deueloped during Second World Wsn uros used to detoxify certain uror poison.Oxidation Reduction Hydrolysis & Conjugation.
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Published 08/05/22