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As good scientific investigators, we strive to make our research more reproducible, repeatable, and translatable. These traits are ostensibly engrained in researchers from the start of their careers but often fall to the wayside in pursuit of experimental answers. Throughout this three-episode podcast series, sponsored by The Baker Company, we will weave the common thread of these essential research traits and discuss some ubiquitous techniques common to so many laboratories—focusing on areas...

Single-use systems have been steadily climbing toward the top of the tools utilized by biomanufacturers for the commercial-scale production of critical therapeutic products. However, COVID-19 created an inflection point for this technology, generating an even greater demand that will shape the market for many years. Yet, with considerable demand comes the need to focus on the key aspects driving growth while discovering the appropriate solutions to the challenges that invariably arise when...

The demand for safe and efficacious biologics has accelerated exponentially in the past several years due to the tremendous success of some of the initial therapeutic offerings in this space. Yet, along with this increased demand comes the need for innovative solutions to improve downstream production workflows. For example, eliminating purification bottlenecks and improving overall yields from chromatography steps can significantly impact the final product’s cost. In this second episode of...

The success and applications of cell and gene therapies are seemingly limitless, and economic forecasts project a compound annual growth rate of almost 40% over the next eight years. This rapid expansion is a double edge sword for biomanufacturers of cell and gene therapy products. On the one hand, the tremendous growth is excellent for business. Yet, on the flip side, biomanufacturers are faced with solving the numerous challenges of scaling-up production workflows: from raw material...

This is the final episode in our three-part GENcast series, where we discuss the virtues of mechanistic modeling and how it can significantly impact critical decision-making points in the drug discovery process, especially as drug developers move closer toward the IND process. In our two previous podcasts, we were introduced to mechanistic modeling concepts and the basics of how they can be applied to drug discovery workflows. You can listen to the earlier podcasts with the following...

This is part two in our three-part GENcast series, where we discuss various aspects of the drug discovery and development process and, in particular, how advanced computational techniques like mechanistic modeling can help advance the therapeutic drug pipeline for many developers. In our initial podcast, we were introduced to mechanistic modeling concepts and the basics of how they can be applied to drug discovery workflows. In this latest GENcast, I sat down once again with Dr. John Burke,...

The drug discovery and development process can be an arduous endeavor. Manufacturers spend considerable resources and money chasing down potential candidate molecules to create a potential new therapeutic—often resulting in abandoning the candidate in the very later stages of development due to minor factors that might have been overlooked at the onset of the discovery process. Thankfully, there have always been those investigators who sought to merge the fields of mathematics and biology...

GEN Biotechnology is the new peer-reviewed journal launching in early 2022 by Mary Ann Liebert Inc. aiming to publish outstanding original research and perspectives across the biotech field. In this Q&A, GEN Biotechnology Senior Editor, Fay Lin, PhD, interviews Editor-in-Chief, Hana El-Samad, PhD, about her scientific research, outreach, and vision for the journal. Learn more about GEN Biotechnology: Website: www.genbiotechjournal.com Twitter: @GENBiotechJrnl Send editorial...

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Navigating the Regulatory Terrain for CDMO’s during Cell & Gene Therapy Production by Genetic Engineering and Biotechnology News

Solve Your Biotherapeutic Challenges with Help from Gene Therapy University by Genetic Engineering and Biotechnology News

Engineered Therapy: Ramping Up CAR-T Biomanufacturing Goals by Genetic Engineering and Biotechnology News

Gretchen Kusek, PhD, Associate Director Scientific Services, and Bart Smits, PhD, Manager Genetic Sciences and Compliance, discuss the key considerations when breeding gene-edited animals using CRISPR, particularly in the context of mosaicism.

Collaborating for Filtration Success, Virtually by Genetic Engineering and Biotechnology News

Back to the Lab – Embracing Change by Genetic Engineering and Biotechnology News

Virtual Becomes Reality for Biopharma Vaccine Development by Genetic Engineering and Biotechnology News

Digital Tools Push Single-Use Technology Challenges to the Side by Genetic Engineering and Biotechnology News

The Quiet Voice of Immunotherapy That's Starting to Be Heard by Genetic Engineering and Biotechnology News

With regions of the world cycling through societal re-openings and shutdowns due to the ongoing coronavirus pandemic, pharma and life science companies are tasked with trying to find creative solutions that help keep production lines moving, as well as drive innovation forward. For instance, pharmaceutical manufacturers still need to meet critical project timelines so that patients receive the therapies they require. As such, many companies require varying levels of technical support to...

David Sorrell, PhD, from Horizon Discovery, speaks with GEN about the importance of cell models in the drug discovery process.

GENcast: CRISPR Screens Speed Drug Discovery Efforts for Disease Intervention by Genetic Engineering and Biotechnology News

Impact of COVID-19 on the Life Sciences Industry by Genetic Engineering and Biotechnology News

Trends in Bioprocess 4.0 and their Impact on Biomanufacturing by Genetic Engineering and Biotechnology News