Global governance failures and economic disparity influence the evolution of a variety of other global risk; most of them are tightly connected. Disconnection through Connection: new, intertwined global challenges and global shifts of power bear the risk of a marginalization of traditional partnerships and multinational institutions. What are the consequences for Europe and the US? Will the transatlantic relationship remain a core element of Western political influence or is it in agony? A bold and long-term strategic vision for the transatlantic community needs to reinvigorate the transatlantic relationship by promoting a global democratic political culture (that respects specific cultural aspects) and fostering a regional cooperative model in a multi-polar and increasingly complex geopolitical setting.