There has been and continues to be no shortage of threats to the United States and the world at large. The global landscape is lined with challenges that seem broad and interconnected. The world of today is a crucible of problems and threats that affect us in ways once unthinkable: terrorism; piracy; hunger and humanitarian concerns; pandemics; climate change; demands for highly strategic resources including energy, food and water; cyber security; proliferation of nuclear, chemical and biological weapons; global economic concerns; and regional instabilities. They are abundant in number and can defy predictability. They require strategic thinking and planning so as to anticipate, prevent and deal with them effectively in times of crisis. This talk will explore those threats and suggest necessary thinking and responses.