Rob is entering his 60s and committing to a better diet…with the help of the esteemed Dr. Mark Hyman! Dr. Mark Hyman (renowned physician, medical advisor to the Clintons, and the host of “The Doctor's Farmacy” podcast) joins Rob Lowe to discuss the Ozempic revolution, the real key to longevity, the obesity statistic that shocked Rob, what foods to avoid, and the easy-to-find snacks that just might help you live longer.  Got a question for Rob? Call our voicemail at (323) 570-4551. Your...

Comedian, actor, and podcaster Paul Scheer joins Rob Lowe to discuss celebrity-owned restaurants, the “M*A*S*H” theme song, why the team behind “The League” decided to end the show while they were still on top, Rob’s traumatic childhood talent show memory, the greatest audition story ever, and Paul’s new memoir, “Joyful Recollections of Trauma.” Pre-order “Joyful Recollections of Trauma” now - out May 21st! Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could...

Kelly Ripa joins Rob Lowe to discuss getting “knighted” by Disney, the joys of working with her husband, why Rob was one of Kelly’s favorite guest co-hosts, trying out the Oculus headset, Rob’s 60th birthday party, her podcast “Let's Talk Off Camera with Kelly Ripa,” and her big goal to get out of hair and makeup! Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Katey and Rob looooove talking to other sober people! Actress and musician Katey Sagal joins Rob Lowe to discuss her new podcast with husband Kurt Sutter, the joys of sobriety, the passing of her godfather Norman Lear, being a Keith Richards girl, working with the amazing John Ritter, why “Sons of Anarchy” convinced Rob to go buy a biker jacket, being of service, and much more.  Listen to Katey’s new podcast, “PIE with Kurt Sutter and Katey Sagal!” Got a question for Rob? Call our voicemail...

Tig and Rob are silent laughers. Comedian Tig Notaro joins Rob Lowe to discuss their shared obsession with the song “Do They Know It’s Christmas?” by Band Aid, her foolproof method for testing potential TV show titles, her love for drama and despair, her podcast “Handsome,” and her new comedy special, “Hello Again.” Plus, Rob reveals a bit of White House trivia he learned shooting “The West Wing.” Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured...

Rob is a huge admirer of the incredible activist and R&B musician Daryl Davis. He is the first Black author to write a book on the Ku Klux Klan (KKK) based on in-person interviews, and he has convinced dozens of Klansmen to leave and denounce the hate group. Today, Daryl joins Rob to discuss his incredible activism work, the power of conversation, his experiences meeting with the KKK as a Black man, and playing with legends like Chuck Berry and B.B. King. Got a question for Rob? Call our...

Rob Lowe and Ted Sarandos love to quote their favorite movies together! Co-CEO of Netflix (and film fanatic) Ted Sarandos joins Rob Lowe to discuss his early days as a video store manager in Arizona, the little-seen Netflix comedy series that he is obsessed with, how the Netflix algorithm and his own fandom led to the company’s deal with Adam Sandler, what AI could mean for the entertainment industry, and much more. Plus, Rob shares one of his favorite golf memories! Got a question for Rob?...

This episode of “Literally” is unlike any other. Rob Lowe is joined by Nando Parrado, one of the 16 survivors of the Uruguayan Air Force Flight 571, which crashed in the Andes mountains in 1972. After spending 72 days trapped in the mountains, Nando, along with his friend and teammate, climbed through the Andes mountains for 10 days to find help.  Nando Parrado talks to Rob Lowe about his incredible story of survival, faith, and teamwork. They also discuss the new film adaptation of Nando’s...

Hilary and Rob go waaaaaaaay back! Hilary Swank joins Rob Lowe to discuss her baby twins, being called “too half-hour” by a CBS executive, the photoshoot she did for Rob and Sheryl in the 90’s, the incredible animal rescue work Hilary did in the wake of 9/11, skiing with Clint Eastwood, memories from the Oscars, and why she feels her father would be proud to see her new film, “Ordinary Angels.” Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on...

Jon and Rob have been in the same circles for decades, but now they are finally getting some quality time together! Jon Cryer joins Rob Lowe to discuss the Brat Pack days, auditioning for "St. Elmo's Fire," the surprising connection between Jon’s mom and Rob’s mom, working with Charlie Sheen on "Two and a Half Men," and Jon’s new sitcom, "Extended Family." Plus, a fan asks Rob to decide: if he could only listen to one album for the rest of his life, what album would it be? Got a question...

Rob and Rev Run are kindred spirits! The legendary rapper, DJ, and minister Rev Run joins Rob Lowe to discuss the incredible legacy of his group Run-DMC, growing up in the sixties and seventies, focusing on family, finding inspiration in the tub, and the new Peacock docuseries, "Kings From Queens: The Run DMC Story.” Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Cheryl and Rob have so much to catch up on! Cheryl Hines joins Rob Lowe to discuss the final season of “Curb Your Enthusiasm,” Larry David’s run-in with Elmo, how she would dress as First Lady, choosing your Secret Service code-name, Cheryl’s mom’s birthday at Thunder Down Under, and much more.  Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

In honor of her 70th birthday, Rob is looking back at his 2021 conversation with the amazing Oprah Winfrey! The two friends discuss what it means to live in gratitude, the wisdom of Toni Morrison, meeting your heroes, and so much more.

Rob and filmmaker Ed Zwick have so many great memories from shooting their 1986 film “About Last Night!” Filmmaker Ed Zwick (creator of “thirtysomething” and director of “The Last Samurai” and “Legends of the Fall”) joins Rob to revisit “About Last Night,” and discuss Ed’s work with Tom Cruise, the death of a certain kind of adult drama film, advice from Morgan Freeman, and Ed’s new book, “Hits, Flops, and Other Illusions: My Fortysomething Years in Hollywood” (out February 13th). Got a...

Rob wouldn't mind swapping lives with Hollywood legend Brian Grazer for a day! The prolific film and TV producer (whose credits include “24,” “Arrested Development,” “Apollo 13,” and “A Beautiful Mind”) joins Rob to discuss the future of Hollywood, how to revamp the Oscars ceremony, the differing worldviews of “The West Wing” and “24,” his book on the power of face-to-face conversation, and his latest film, “Candy Cane Lane” with Eddie Murphy.  Got a question for Rob? Call our voicemail at...

It’s a love-fest when old friends Robert Downey Jr. and Rob Lowe get together! Rob is talking to his former high school classmate and longtime friend: the great Robert Downey Jr. Hear them discuss their shared memories from Santa Monica High School, surviving the 1980s, the genius of Christopher Nolan, and growing from set-backs. Robert’s latest film, “Oppenheimer,” is available now on 4K, Blu-Ray, DVD & Digital. His book, "Cool Food: Erasing Your Carbon Footprint One Bite at a Time"...

Ted Danson and Rob Lowe have watched the entertainment industry transform! Ted Danson joins Rob Lowe to discuss the incredible legacy of “Cheers,” the optimistic comedy of “The Good Place” and “Parks & Recreation,” his experiences working with Steven Spielberg and Larry David, learning that his show was canceled while touring the Sistine Chapel, and the importance of protecting our oceans. Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on...

When Darius Rucker and Rob Lowe get together, it's time to talk sports and music! Darius Rucker joins Rob Lowe to discuss the early days of Hootie & the Blowfish, the compliment he received from Frank Sinatra, why “Wagon Wheel” is so undeniable (and the song’s surprising co-writer), Darius’ new sports swag collection with Fanatics, and his upcoming Hootie & the Blowfish anniversary tour. Plus, Rob tells us his go-to karaoke songs. Got a question for Rob? Call our voicemail at (323)...

As a holiday gift to his Literally listeners, Rob is revisiting one of his all-time favorite episodes: his 2021 chat with Molly Ringwald! Hear them discuss her iconic work with John Hughes, Rob’s audition for “The Breakfast Club,” Bop! vs Time Magazine, how she found her voice as a writer, and much more! This episode originally aired 8/2/2021.  Got a question for Rob? Leave a 30-second voicemail at (323) 570-4551. Your question could get featured on the show!

Jerry O’Connell and Rob Lowe never stopped hustling! Actor and host Jerry O’Connell joins Rob Lowe to discuss his unexpected path to daytime television, their similar experiences shooting "Stand By Me" and "The Outsiders," raising teenagers in a changing world, the career insecurities that never go away, his new season of “The Talk,” and much more. Plus, Rob talks about his Christmas movie, "Holiday in the Wild." Got a question for Rob? Leave a 30-second voicemail at (323) 570-4551. Your...

As a holiday gift to his Literally listeners, Rob is revisiting one of his all-time favorite episodes: his 2021 chat with Jennifer Aniston! Hear them talk haircuts, headshots, and the “Friends” reunion on HBO Max. This episode originally aired 9/16/2021. Got a question for Rob? Leave a 30-second voicemail at (323) 570-4551. Your question could get featured on the show!

Christmas came early here on Literally! Katharine McPhee and David Foster join Rob Lowe to discuss their new album, “Christmas Songs,” Rob and David’s decades of friendship, why Rob prefers classic Christmas songs, the surprising origins of the “St. Elmo's Fire” theme, the genius of Celine Dion, and the incredible story of how Rob and David managed to prank both President Clinton and Barbra Streisand.

Nikki Glaser returns to Literally for even more laughs! Comedian Nikki Glaser talks to Rob about hosting "FBoy Island," escaping her parents’ house, being kind to yourself, getting voted off "Dancing With the Stars," why David Spade is underrated, cutting back on curse words, and teenaged Rob’s attempt to impress the cool Malibu surfers. Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

John Owen Lowe literally can’t resist teasing his father! Writer/actor John Owen Lowe joins Rob Lowe to discuss the upcoming second season of their show “Unstable” on Netflix, why he doesn’t listen to his dad’s podcast, how John Stamos ended up on the Lowe family Christmas card, what Rob is like as a father, and much more. Plus, Sheryl Lowe calls in to ask some important questions about John’s dating life!  Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get...