In this live episode of the MASS Office Hours podcast, Dr. Eric Trexler and Lauren Colenso-Semple answer questions on topics like changing training programs based on menstrual cycle phase, sex differences in muscle fatigue, the impact of sleep on gains, the effects of caffeine on sleep quality, metabolism, applying research to practice, teaching exercises to beginners, and more. The MASS crew goes live for Office Hours every Wednesday night at 7pm eastern time. Be sure to join us for a future episode! Our next episode will begin at 7pm on November 15. If you'd like to submit a question, please use this link: https://forms.gle/9Ah39mefs8cuVa9H7 Time stamps:  0:00 Introduction 3:52 Should training change based on menstrual cycle phase? 13:45 Are there meaningful sex-based differences in muscle fatigue 20:00 What is the impact of caffeine on sleep? 30:51 How does sleep affect hypertrophy and strength outcomes? 57:18 Besides adding muscle mass, is there a way to boost metabolism? 1:05:09 To what degree should research guide practice? 1:17:29 What rep ranges are best for learning a brand new exercise? 1:30:43 Eric’s reflections on his early work as a strength and conditioning coach 1:36:32 Concluding remarks