Featuring articles on treatments in newly diagnosed chronic myeloid leukemia and RNA therapeutics in mixed hyperlipidemia; a review article on clinical approaches to firearm injury prevention; a case report of a woman with edema, arthritis, and proteinuria; and Perspectives on keeping SNAP in line with global evidence, on ingesting risk, on centering the peripheral brain, and on how health care burdens patients. Supplement to the New England Journal of Medicine, Vol. 391, No. 10.