There are various types of studies that are necessary to perform in order to determine their clinical relevance. The process extends from benchtop to bedside side and includes various special populations like pediatrics and geriatrics. This course addresses various elements related to the study of analgesics. Novel improved preclinical animal models in analgesic studies are examined. The unique issues of unusually high placebo and nocebo effects in analgesic which can lead to confusing results are discussed. The role and responsibilities of acting as a Principal Investigator in an analgesic trial are discussed. The practical impact of new healthcare measures and the increased the importance of comparative effectiveness trials and health outcomes and pharmacoeconomic are reviewed. The process of publishing data and determination of authorship At the conclusion of the program participants shall have a comprehensive understanding of the analgesic trials.