All episodes of PaperPlayer biorxiv cancer biology

Episodes

Lineage transcription factors co-regulate subtype-specific genes providing a roadmap for systematic identification of small cell lung cancer vulnerabilities

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.13.249029v1?rss=1 Authors: Pozo, K., Kollipara, R. K., Kelenis, D. P., Rodarte, K. E., Zhang, X., Minna, J. D., Johnson, J. E. Abstract: Lineage-defining transcription factors (LTFs) play key roles in tumor cell growth, making them highly attractive, but currently undruggable, small cell lung cancer (SCLC) vulnerabilities. Delineating LTF genomic binding sites and associated chromatin features would provide important...

Published 08/14/20

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.12.246660v1?rss=1 Authors: Huang, L., Zhang, X.-O., Verdejo-Torres, O., Wigglesworth, K., Sun, X., Sallis, B., Moon, D., Huang, T., Rozen, E., Zhang, L., Wang, G., Shohet, J. M., Lee, M. M., Wu, J. Q. Abstract: Protein arginine methyltransferase 5 (PRMT5) generates most of the symmetric di-methyl-arginine marks on histones and non-histone proteins by which it regulates a wide range of physiological processes including...

Published 08/13/20

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.12.247817v1?rss=1 Authors: Talwelkar, S. S., Mäyranpää, M. I., Soraas, L., Potdar, S., Bao, J., Hemmes, A., Linnavirta, N., Lomo, J., Räsänen, J., Knuuttila, A., Wennerberg, K., Verschuren, E. W. Abstract: Functional profiling of a cancer patient's tumor cells holds potential to tailor personalized cancer treatment. Here we report the utility of Fresh Uncultured Tumor-derived EpCAM+ epithelial Cells (FUTC) for ex...

Published 08/13/20

EGFR transactivates RON to drive oncogenic crosstalk

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.11.246785v1?rss=1 Authors: Franco Nitta, C., Green, E. W., Jhamba, E. D., Keth, J. M., Ortiz-Caraveo, I., Grattan, R. M., Schodt, D. J., Gibson, A. C., Rajput, A., Lidke, K. A., Steinkamp, M. P., Wilson, B. S., Lidke, D. S. Abstract: Crosstalk between disparate membrane receptors is thought to drive oncogenic signaling and allow for therapeutic resistance. EGFR and RON are members of two unique receptor tyrosine kinase...

Published 08/12/20

Targeting KRAS-mutant stomachcolorectal tumours by disrupting the ERK2-p53 complex

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.12.247460v1?rss=1 Authors: Lang, J.-Y., Wang, X., Xie, Q., Ji, Y., Shen, J., Wang, C., Jiang, X., Chen, Z., Zhang, Y., Kong, X., Ding, J. Abstract: KRAS is widely mutated in human cancers, resulting in nearly unchecked tumour proliferation and metastasis. No therapies have been developed for targeting KRAS-mutant tumours. Herein, we observed that KRAS-mutant stomach/colorectal tumour cells were hypersensitive to the...

Published 08/12/20

Preclinical modeling of surgery and steroid therapy for glioblastoma reveals changes in immunophenotype that are associated with tumor growth and outcome

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.12.248443v1?rss=1 Authors: Otvos, B., Alban, T. J., Grabowski, M. M., Bayik, D., Mulkearns-Hubert, E. E., Radivoyevitch, T., Rabljenovic, a., Johnson, S., Androjna, C., Mohammadi, A. M., Barnett, G., Ahluwalia, M. S., Vogelbaum, M. A., Fecci, P. E., Lathia, J. D. Abstract: Recent advances in cancer immunotherapy have created a greater appreciation of potential anti-tumoral impacts by the immune system; however, individual...

Published 08/12/20

ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.12.248559v1?rss=1 Authors: Constantin, D., Widmann, C. Abstract: It is of clinical importance to identify biomarkers predicting the efficacy of DNA damaging drugs (genotoxins) so that non-responders are not unduly exposed to the deleterious effects of otherwise inefficient drugs. Using a whole genome CRISPR/Cas9 gene knockout approach we have identified that low levels of ASH2L cause resistance to genotoxins. ASH2L is a...

Published 08/12/20

Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT states

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.11.245787v1?rss=1 Authors: Simeonov, K. P., Byrns, C. N., Clark, M. L., Norgard, R. J., Martin, B., Stanger, B. Z., McKenna, A., Shendure, J., Lengner, C. J. Abstract: Metastatic cancer remains largely incurable due to an incomplete understanding of how cancer cells disseminate throughout the body. However, tools for probing metastatic dissemination and associated molecular changes at high resolution are lacking. Here we...

Published 08/12/20

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.11.246777v1?rss=1 Authors: Kim, J. H., Megquier, K. J., Thomas, R., Sarver, A. L., Song, J. M., Kim, Y. T., Schulte, A. J., Cheng, N., Linden, M. A., Murugan, P., Oseth, L., Foster, C. L., Elvers, I., Swofford, R., Turner-Maier, J., Karlsson, E. K., Breen, M., Lindblad-Toh, K., Modiano, J. F. Abstract: Sporadic angiosarcomas (ASs) are aggressive vascular sarcomas whose rarity and genomic complexity present significant...

Published 08/12/20

IGF targeting perturbs global replication through ribonucleotide reductase dysfunction

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.11.245886v1?rss=1 Authors: Rieunier, G., Wu, X., Harris, L., Mills, J., Nandakumar, A., Colling, L., Seraia, E., Hatch, S. B., Ebner, D., Folkes, L., Weyer-czernilofsky, U., Bogenrieder, T., Ryan, A. J., Macaulay, V. M. Abstract: IGF receptor (IGF-1R) inhibition delays repair of radiation-induced DNA double-strand breaks (DSBs), prompting us to investigate whether IGF-1R influences endogenous DNA damage. We demonstrate...

Published 08/12/20

CEBPB-dependent Adaptation to Palmitic Acid Promotes Stemness in Hormone Receptor Negative Breast Cancer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.11.244509v1?rss=1 Authors: Liu, X., Rulina, A., Choi, M. H., Pedersen, L., Lepland, J., Madeleine, N., Peters, S., Wogsland, C. E., Grondal, S. M., Lorens, J., Goodarzi, H., Molven, A., Lonning, P. E., Knappskog, S., Halberg, N. Abstract: Epidemiological studies have established a positive association between obesity and the incidence of postmenopausal (PM) breast cancer. However, the molecular mechanisms underlying this...

Published 08/11/20

Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.10.243154v1?rss=1 Authors: Palanikumar, L., Karpauskaite, L., Hassan, S., Alam, M., Al-Sayegh, M., Chehade, I., Maity, D., Ali, L., Falls, Z., Samudrala, R., Kalmouni, M., Hunashal, Y., Ahmed, J., Karapetyan, S., Pasricha, R., Esposito, G., Afzal, A. J., Hamilton, A. D., Kumar, S., Magzoub, M. Abstract: Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The vast majority of...

Published 08/11/20

Cell Ecosystem and Signaling Pathways of Primary and Metastatic Pediatric Posterior Fossa Ependymoma

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.10.244483v1?rss=1 Authors: Aubin, R., Troisi, E. C., Alghalith, A. N., Nasrallah, M. P., Santi, M., Camara, P. G. Abstract: Pediatric ependymoma is a devastating brain cancer marked by its relapsing pattern and lack of effective chemotherapies. This shortage of treatments is partially due to limited knowledge about ependymoma tumorigenic mechanisms. Although there is evidence that ependymoma originates in radial glia, the...

Published 08/10/20

Constitutive Androstane Receptor and Hepatitis B Virus X Protein Cooperatively Induce β-catenin-Activated Liver Tumors

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.08.241661v1?rss=1 Authors: Scott, J., Liu, S., Klatt, K., Sun, Z., Guo, Q., Grimm, S., Coarfa, C., Dong, B., Moore, D. D. Abstract: Background and Aims: The xenobiotic nuclear receptor Constitutive Androstane Receptor (CAR) is essential for xenobiotic tumor promotion in mouse models. In these models, {beta}-catenin is genetically activated in approximately 80% of tumors. Chronic Hepatitis B Virus (HBV) infection is a...

Published 08/10/20

An AI-powered blood test to detect cancer using nanoDSF

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.09.242818v1?rss=1 Authors: Tsvetkov, P. O., Eyraud, R., Ayache, S., Bougaev, A. A., Malesinski, S., Benazha, H., Gorokhova, S., Buffat, C., Dehais, C., Sanson, M., Bielle, F., Figarella-Branger, D., Chinot, O., Tabouret, E., Devred, F. Abstract: We describe a novel cancer diagnostic method based on plasma denaturation profiles obtained by a non-conventional use of Differential Scanning Fluorimetry. We show that 84 glioma...

Published 08/10/20

Mutant-selective Degradation by BRAF-targeting PROTACs

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.10.245159v1?rss=1 Authors: Alabi, S., Jaime-Figueroa, S., Yao, Z., Gao, Y., Hines, J., Samarasinghe, K. . T. G., Vogt, L., Rosen, N., Crews, C. M. Abstract: Over 300 BRAF missense mutations have been identified in patients, yet currently approved drugs target V600 mutants alone. Moreover, acquired resistance inevitably emerges, primarily due to RAF lesions that prevent inhibition of BRAF V600 with current treatments....

Published 08/10/20

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.10.238428v1?rss=1 Authors: Reinfeld, B. I., Madden, M. Z., Wolf, M. M., Chytil, A., Bader, J. E., Patterson, A. R., Cohen, A. S., Ali, A., Do, B. T., Lewis, C. A., Muir, A., Hongo, R. A., Young, K. L., Brown, R. E., Todd, V. M., Huffstater, T., Abraham, A., O'Neil, R. T., Wilson, M. T., Xin, F., Tantawy, M. N., Merryman, W. D., Johnson, R. W., Williams, C. S., Mason, E. F., Mason, F. M., Beckermann, K. E., Vander Heiden, M....

Published 08/10/20

SMARCA4 deficient tumours are vulnerable to KDM6AUTX and KDM6BJMJD3 blockade

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.07.241232v1?rss=1 Authors: Romero, O. A., Villarrubi, A., Alburquerque-Bejar, J. J., Gomez, A., Andrade, A., Trastulli, D., Pros, E., Verdura, S., Farre, L., Martin-Tejera, J. F., Llabata, P., Oaknin, A., Saigi, M., Piulats, J. M., Matias-Guiu, X., Medina, P. P., Vidal, A., Villanueva, A., Sanchez-Cespedes, M. Abstract: Despite the genetic inactivation of SMARCA4, a core component of the SWI/SNF-complex commonly found in...

Published 08/07/20

Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.06.238345v1?rss=1 Authors: Chen, J.-W. E., Lumibao, J. C., Leary, S., Sarkaria, J., Steelman, A., Gaskins, R., Harley, B. Abstract: Background Glioblastoma is the most common and deadly form of primary brain cancer, accounting for more than thirteen thousand new diagnoses annually in the United States alone. Microglia are the innate immune cells within the central nervous system, acting as a front-line defense against...

Published 08/07/20

Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.07.232322v1?rss=1 Authors: Heij, L. R., Tan, X., Kather, J. N., Niehues, J. M., Sivakumar, S., Heussen, N., van der Kroft, G., Olde Damink, S. W. M., Lang, S., Bednarsch, J., Aberle, M. R., Luedde, T., Gaisa, N., Liu, D. H. W., Cleutjens, J. P. M., Modest, D. P., Wiltberger, G. J., Neumann, U. P. Abstract: Background: B cells and tertiary lymphoid structures (TLS) are reported to be important in the improvement of...

Published 08/07/20

PELP1SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.07.238550v1?rss=1 Authors: Truong, T. H., Benner, E. A., Hagen, K. M., Temiz, N. A., Perez Kerkvliet, C., Wang, Y., Pengo, T., Guillen, K. P., Welm, B. W., Telang, S., Lange, C. A., Ostrander, J. H. Abstract: Recurrence of metastatic breast cancer stemming from acquired endocrine and chemotherapy resistance remains a health burden for women with luminal (ER+) breast cancer. Disseminated ER+ tumor cells can remain viable...

Published 08/07/20

The Pancreatic Tumor Microenvironment Buffers Redox Imbalance Imposed by Disrupted Mitochondrial Metabolism

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.07.238766v1?rss=1 Authors: Kerk, S. A., Lin, L., Myers, A. L., Chen, B., Sajjakulnukit, P., Robinson, A., Thurston, G., Nelson, B. S., Kemp, S. B., Steele, N. G., Hoffman, M. T., Wen, H.-J., Long, D., Ackenhusen, S. E., Ramos, J., Gao, X., Zhang, L., Andren, A., Nwosu, Z. C., Galban, S., Halbrook, C. J., Lombard, D. B., Ying, H., Crawford, H. C., Pasca di Magliano, M., Shah, Y. M., Lyssiotis, C. A. Abstract: The tumor...

Published 08/07/20

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.04.235697v1?rss=1 Authors: Hutchinson, S. A., Websdale, A., Lianto, P., Cioccoloni, G., Roberg-Larsen, H., Kim, B., Rose, A., Soteriou, C., Wastall, L. M., Williams, B., Henn, M., Chen, J. J., Ma, L., Moore, J. B., Nelson, E. R., Hughes, T. A., Thorne, J. L. Abstract: Triple negative breast cancer (TNBC) is challenging to treat successfully because targeted therapies do not exist. Instead, systemic therapy is typically...

Published 08/06/20

PaperPlayer biorxiv cancer biology

Published 08/06/20

Gluconeogenic Enzyme PCK1 Deficiency Is Critical for CHK2 O-GlcNAcylation and Hepatocellular Carcinoma Growth upon Glucose Deprivation

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.06.240739v1?rss=1 Authors: Xiang, J., Chen, C., Liu, R., Gou, D., Chang, L., Deng, H., Gao, Q., Zhang, W., Tuo, L., Pan, X., Liang, L., Xia, J., Huang, L., Huang, A., Wang, K., Tang, N. Abstract: Elevated hexosamine-biosynthesis pathway (HBP) activity and O-GlcNAcylation are emerging hallmarks of hepatocellular carcinoma (HCC). Inhibiting O-GlcNAcylation could be a promising anti-cancer strategy. Here, we investigate this...

Published 08/06/20