In this special episode Alex R. Kemper, MD, MPH, MS, FAAP, lead author of the clinical practice guideline, Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation, explains the importance of measuring total serum bilirubin in newborns. He tells hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, the 2022 guideline offers clarification on when to start phototherapy and when to give an exchange transfusion. For resources go to aap.org/podcast.