The topic of hypertension is of paramount clinical importance as a significant risk factor for cardiovascular disease, myocardial infarction, stroke, and kidney disease. Sex differences in blood pressure regulation play a major role in the pathophysiology of hypertension. In the episode, Dr. Carol Ann Remme (University of Amsterdam) interviews Dr. Thu Le (University of Rochester) about her new Review in Physiological Reviews on the renal, hemodynamic, and hormonal mechanisms of sexual dimorphism in blood pressure homeostasis. We discuss sex chromosome effects, hormonal changes, potential sex differences related to innate and adaptive immunity, and the clinical relevance of animal models to develop new therapeutic targets. Listen now and learn more.   Erika R. Drury, Jing Wu, Joseph C. Gigliotti, Thu H. Le Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms Physiological Reviews, published October 16, 2023. DOI: 10.1152/physrev.00041.2022