In our latest episode, Dr. Farrah Kheradmand (Baylor College of Medicine) interviews Dr. Kevin Harrod (University of Alabama at Birmingham) about his article by Patton et al. on community-acquired bacterial coinfections and COVID-19. In the early days of the pandemic when physicians were treating critically ill COVID patients, there was no standard definition for bacterial coinfections in this cohort. However, as the field has moved forward with understanding how bacterial coinfections...

The topic of hypertension is of paramount clinical importance as a significant risk factor for cardiovascular disease, myocardial infarction, stroke, and kidney disease. Sex differences in blood pressure regulation play a major role in the pathophysiology of hypertension. In the episode, Dr. Carol Ann Remme (University of Amsterdam) interviews Dr. Thu Le (University of Rochester) about her new Review in Physiological Reviews on the renal, hemodynamic, and hormonal mechanisms of sexual...

In this episode of The Physiological Reviews Podcast, Professor Giovanni Mann (King’s College London) interviews authors Prof. Marzia Perluigi (Sapienza University of Rome) and Prof. D. Allan Butterfield (University of Kentucky) about their recently published Review on the oxidative stress hypothesis of Alzheimer Disease. The authors provide a comprehensive overview of amyloid beta-peptide associated mechanisms, the use of redox proteomics to define roles of lipid and protein oxidation, and...

As Sir Winston Churchill once said, “Where there is great power, there is great responsibility.” This is the overarching context of our latest episode about the future of artificial intelligence (AI) in physiology and healthcare. Listen as host Dr. Ryan Melvin (University of Alabama at Birmingham) interviews author Dr. James Zou (Stanford University) about the Review by Zhang et al. on “Leveraging Physiology and Artificial Intelligence to Deliver Advancements in Healthcare AI in Physiology...

What are the key physiological adaptations attained in exercise regimens used by elite athletes to achieve peak performance? In our latest episode of The Physiological Reviews Podcast, Editor-in-Chief Dr. Sadis Matalon (University of Alabama at Birmingham) interviews author and Physiological Reviews Associate Editor Dr. Christoph Handschin (University of Basel, Switzerland) about the new Review by Furrer et al. As Dr. Handschin explains, the basis of all types of muscle adaptations is...

Genetics studies, including genome-wide association studies (GWAS), play an increasingly important role in physiology and pathophysiology studies of cardiovascular disease. Listen as Deputy Editor Dr. Carol Ann Remme interviews authors Prof. Jeanette Erdmann (University of Lübeck, Germany) and Prof. Connie Bezzina (Amsterdam University Medical Center, Netherlands) about their latest Review in Physiological Reviews by Walsh et al. GWAS are aimed at identifying genetic variants for specific...

How do changes in concentration of stratospheric ozone impact human health and the global ecosystem? In our latest episode Editor-in-Chief Dr. Sadis Matalon interviews lead author Professor Christos Zerefos about the recent Review titled, “The long-term variability of human health related solar ultraviolet-B radiation doses from the 1980s to the end of 21st century.” Because stratospheric ozone is the protective layer which screens harmful UV-B solar radiation, ozone depletion impacts...

Physiological Reviews Associate Editor Prof. Christoph Handschin speaks with Prof. Paul L. Greenhaff and Prof. Janet M. Lord about their article “Multisystem Physiological Perspective of Human Frailty and Its Modulation by Physical Activity,” published in the April 2023 issue of Physiological Reviews. Prof. Greenhaff is Professor at the School of Life Sciences at the University of Nottingham and is deputy director of the Medical Research Council (MRC)-Versus Arthritis Centre for...

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Dr. Paule V. Joseph about her article “A Systematic Review of the Biological Mediators of Fat Taste and Smell,” the first systematic review to be published in Physiological Reviews. Dr. Joseph is Lasker Clinical Research Scholar, Tenure Track Clinical Investigator, and Chief of the Section of Sensory Science and Metabolism in the Division of Intramural Clinical and Biological Research at the National Institute of Alcohol...

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with   Prof. John P.A. Ioannidis about his editorial “Systematic Reviews for Basic Scientists: A Different Beast,” which focuses on the importance of systematic reviews in scientific research. Prof. Ioannidis is Professor of Medicine, of Epidemiology and Population Health, and, by courtesy, of Statistics and Biomedical Data Science at Stanford University. He is one of the most cited scientists in the world and is an elected member...

Physiological Reviews Associate Editor Prof. Giovanni Mann speaks with Prof. Rafael Radi about his review article “The superoxide radical switch in the biology of nitric oxide and peroxynitrite,” about the life of a scientist, and about advice for early-career researchers. Prof. Radi is Professor, Chair, and Director of the Centro de Investigaciones Biomédicas (CEINBIO) at the Universidad de la República in Montevideo, Uruguay. Prof. Radi has made significant contributions to our...

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Prof. Rebecca M. Reynolds, Prof. Sarah J. Stock, and Prof. Hilary O. D. Critchley about their editorial “Pregnancy and the SARS-CoV-2 Pandemic,” published in the July 2022 issue of Physiological Reviews. The authors also have contributed a review article on this topic, “Pregnancy and COVID-19,” which was one of the most highly cited articles published in the journal in 2021. Prof. Reynolds is Professor of Metabolic Medicine...

Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with Michael Saag, MD, of the University of Alabama at Birmingham (UAB) about his editorial “Wonder of wonders, miracle of miracles: the unprecedented speed of COVID-19 science.” Dr. Saag is Associate Dean for Global Health in the School of Medicine, Director of the UAB Center for AIDS Research and a Professor of Medicine in the Division of Infectious Diseases. He also is the principal investigator of the CFAR Network of...

To follow up on our recently published AIP manuscript “Physiology and Pathophysiology of Human Airway Mucus” (https://doi.org/10.1152/physrev.00004.2021), we were able to connect with senior author Dr. Richard Boucher.   In this podcast, Physiological Reviews Editorial Ken Adler and Dr. Boucher have an interesting conversation on pathogenesis and future therapies in lung and airway diseases.  They discuss everything from mucin genes to Cystic Fibrosis.

Advances in our understanding of brain function, along with the development of neural interfaces that allow for the monitoring and activation of neurons, have paved the way for brain machine interfaces (BMI), which harness neural signals to reanimate the limbs via electrical activation of the muscles, or to control extra-corporeal devices, thereby bypassing the muscles and senses altogether. BMIs consist of reading out motor intent from the neuronal responses monitored in motor regions of the...

Deputy Editor Dr. Willis Samson takes a deep dive into the complex universe that control the behavior and mechanisms of eating.  He is joined by the authors of our recent published review "The Physiological Control of Eating: Signals, Neurons, and Networks" by Alan G. Watts, Scott E Kanoski, Graciela Sanchez-Watts and Wolfgang Langhans. Learn about the advances of this complicated process and the possible therapeutics for the future. Watts AG, Kanoski SE, Sanchez-Watts G, Langhans W. The...

Dr. Sadis Matalon, editor in Chief and Dr. Sally Wenzel discuss Asthma and her PRV review Are We Meeting the Promise of Endotypes and Precision Medicine in Asthma?  

Editor in Chief, Dr. Sadis Matalon and Dr. MIchael Matthay discuss the lung research and how it moves from the bench to the beside.  Dr. Matthay has had two very well cited reviews published in Physiological Reviews: Lung Epithelial Fluid Transport and the Resolution of Pulmonary Edema Michael A. Matthay, Hans G. Folkesson, and Christine Clerici Physiological Reviews Volume 82, Issue 3 2002 Jan 07       Elevated Plasmin(ogen) as a Common Risk Factor for COVID-19 Susceptibility Hong-Long...

Editor in Chief, Dr. Sadis Matalon and corresponding author Stefano Romagnoli discuss the Covid-19 virus in Italy and beyond including which practices they have successfully taken from the bench to the bedside.

Colette Bean, Chief Publishing Officer of the American Physiological Society, discusses the past, present, and future of Physiological Reviews with Editor-in-Chief, Sadis Matalon, PhD.