Physiological Reviews Editor-in-Chief Dr. Sadis Matalon speaks with   Prof. John P.A. Ioannidis about his editorial “Systematic Reviews for Basic Scientists: A Different Beast,” which focuses on the importance of systematic reviews in scientific research. Prof. Ioannidis is Professor of Medicine, of Epidemiology and Population Health, and, by courtesy, of Statistics and Biomedical Data Science at Stanford University. He is one of the most cited scientists in the world and is an elected member of numerous national academies. Prof. Ioannidis in an Associate Editor of Physiological Reviews. Introduction of Prof. Ioannidis [1:26] Author’s background [3:08] Discussion of reproducibility in science [5:35] Discussion of sample size in research [7:31] What exactly is a systematic review, and how can it address bias? [10:41] Do systematic reviews have a place in basic research, or should they be used mostly in clinical science? [13:29] What is a “living review”? [15:35] What does the future hold for the format of review articles? [18:34] The importance of collaboration in science [21:50] Advice for early-career researchers [24:57] Subscribe to the podcast on Apple Podcasts, Google Podcasts, Spotify, and Amazon Music to receive immediate notification when new episodes are available. Browse recent articles on our website. Be sure to let your colleagues know about the podcast, and please rate and review it wherever you listen to it. Follow the journal on Twitter and Facebook. Listen to other podcasts produced by the American Physiological Society.