Episode #262. Discover the science of getting older without getting old in this conversation with Dr Andrew Steele. From understanding what impacts your lifespan to revealing potential future scientific breakthroughs, this episode is an intriguing journey into the world of aging science. Specifically, we discuss: Intro (00:00) Dr. Andrew Steele on aging (01:38) Age-related diseases and lifespan extension (10:47) Genetic factors, lifestyle, and gene editing for longevity (19:18) Could gene editing help solve poor cholesterol? (27:52) Rapamycin vs metformin for longevity (34:21) The need for expert consensus on anti-aging interventions (39:47) Insights on Bryan Johnson's Project Blueprint (47:50) What are senolytic drugs? (51:24) Yamanaka factors: is aging reversible at a cellular level? (1:05:18) The rationale behind reversing aging and the future of interventions (1:17:42) Lifestyle changes that slow the clock (1:25:40) Calorie restriction and longevity (1:32:41) Air quality, smoking, and vaping (1:44:54) Stress, aging, and telomeres (1:51:18) Are there biological reasons why women tend to live longer? (1:59:05) Unpacking the buzz around HRT for men (2:04:14) Environmental impact of extending human lifespan (2:07:23) Outro (2:14:10) Connect with Dr Andrew Steele on Twitter, Instagram, and Mastodon. Make sure to also head to his YouTube channel, where you’ll find videos on the ethics of prolonging lifespan and whether you can become biologically younger. Discover his book, “Ageless: The new science of getting older without getting old”, at https://andrewsteele.co.uk/ageless/, and read the free chapter on ethics here. Enjoy, friends. Simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book