Welcome to the Olink® Proteomics in Proximity podcast!  Below are some useful resources mentioned in this episode:    UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies    UKB-PPP online resources developed by Nick Lehner and Maria...

Welcome to the Olink® Proteomics in Proximity podcast! Below are some useful resources mentioned in this episode: Olink tools and software• Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/• Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity:...

Welcome to the Olink® Proteomics in Proximity podcast!    Below are some useful resources from this episode:    Published study of primary focus Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C. Proteogenomic links to human metabolic diseases. Nat Metab. 2023 Mar;5(3):516-528. doi: 10.1038/s42255-023-00753-7. Epub 2023 Feb 23. Erratum in: Nat Metab. 2023 Mar 19;: PMID: 36823471; PMCID: PMC7614946....

Welcome to the Olink® Proteomics in Proximity podcast!   Below are some useful resources from this episode:    Published study of primary focus Álvez MB, Edfors F, von Feilitzen K, Zwahlen M, Mardinoglu A, Edqvist PH, Sjöblom T, Lundin E, Rameika N, Enblad G, Lindman H, Höglund M, Hesselager G, Stålberg K, Enblad M, Simonson OE, Häggman M, Axelsson T, Åberg M, Nordlund J, Zhong W, Karlsson M, Gyllensten U, Ponten F, Fagerberg L, Uhlén M. Next generation pan-cancer blood proteome profiling...

Welcome to Olink Proteomics in Proximity Podcast!   Below are some useful resources from this episode:   Highlighted publication: Girerd N, et al. Protein Biomarkers of New-Onset Heart Failure: Insights From the Heart Omics and Ageing Cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. Circ Heart Fail. 2023 May;16(5):e009694. doi: 10.1161/CIRCHEARTFAILURE.122.009694 https://pubmed.ncbi.nlm.nih.gov/37192292/  Large-scale cardiovascular studies: ·       ...

Welcome to Olink Proteomics in Proximity Podcast!    Below are some useful resources from this episode:    Highlighted article from the UK Biobank Pharma Proteomics Project (UKB-PPP): Styrkarsdottir U, Lund SH, Thorleifsson G, Saevarsdottir S, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K. Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource. Arthritis...

Welcome to Olink Proteomics in Proximity Podcast!   Below are some useful resources from this episode:   Highlighted pre-print article: Malarstig A, Grassman F, Dahl L, et al. Evaluation of Circulating Plasma Proteins in Breast Cancer: A Mendelian Randomization Analysis. ResearchSquare 2023.04.04. DOI: https://doi.org/10.21203/rs.3.rs-2749047/v1   Highlighted platform that was used to measure proteins in this study with a next-generation sequencing (NGS) readout (Olink® Explore 3072):...

Welcome to Olink Proteomics in Proximity Podcast!  Below are some useful resources from this episode:  Highlighted publication: Grasberger H, Magis AT, Sheng E, Conomos MP, Zhang M, Garzotto LS, Hou G, Bishu S, Nagao-Kitamoto H, El-Zaatari M, Kitamoto S, Kamada N, Stidham RW, Akiba Y, Kaunitz J, Haberman Y, Kugathasan S, Denson LA, Omenn GS, Kao JY. DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk. J Clin...

Welcome to Olink Proteomics in Proximity Podcast!  Below are some useful resources from this episode:  Highlighted publication: Diaz-Canestro C, Chen J, Liu Y, Han H, Wang Y, Honoré E, Lee CH, Lam KSL, Tse MA, Xu A. A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes. Cell Rep Med. 2023 Feb 21;4(2):100944. doi: 10.1016/j.xcrm.2023.100944. Epub 2023 Feb 13:...

Highlighted publication: Zannad F, Ferreira JP, Butler J, Filippatos G, Januzzi JL, Sumin M, Zwick M, Saadati M, Pocock SJ, Sattar N, Anker SD, Packer M. Effect of empagliflozin on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme. Eur Heart J. (2022) 43(48):4991-5002. doi:10.1093/eurheartj/ehac495. PMID: 36017745; PMCID: PMC9769969. Review paper of research by Voltar Longo and David Sinclair on longevity and aging, mentioning sirtuins and mTOR. Longo...

All about Olink Flex: https://olink.com/flex Olink Insight (where you can build a 21-plex Olink Flex panel from 200 proteins): https://insight.olink.com  Sweden’s Science for Life laboratory website: https://www.scilifelab.se/about-us/ In case you were wondering, Proteomics in Promixity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more information about the assay and how it works can be found here. Would you like to...

A review of a recent publication by Loroit and Italiano et al in Annals of Oncology, identifying a novel predictive biomarker of immune-checkpoint blockade resistance.

A discussion of Alnylam's RNAi therapeutic called patiseran for identification of biomarkers associated with the knockdown of a disease-causing protein transthyretin.

In this episode we discuss a paper titled "Chromatin Remodeling in Response to BRCA2-Crisis" by Dr. Michael Snyder's Stanford laboratory, that tells an interesting multi-omics story of how the BRCA2 inherited cancer gene has multiple functions.

A discussion with a leading multiomics researcher, Dr. Karsten Suhre of Weill Cornell Medicine in Qatar. Plenty of discussion around intermediate phenotypes, metabolomics, genomics and proteomics, and the increasing role of population health projects.

An interview with a data scientist from Olink who was on the development team of the new Olink Insight knowledge platform for proteomics, Hilda Andersson.

The annual American Society of Human Genetics (#ASHG22) conference was held October 25 to 29, 2022 in the Los Angeles Convention Center, and the co-hosts discuss the highlights of the conference and notable trends.

A guest interview with Dr. Ida Grundberg, Chief Scientific Officer of Olink Proteomics, about what it was like in the earliest days of Olink Proteomics, and the journey from the first Nature Communications paper in 2014 until today, 1,000 publications later.

A discussion of a recent Scientific Advances paper by Katz et al comparing aptamer- and antibody-based protein detection methods using genetics and clinical traits, just in time for the American Society for Human Genetics conference (#ASHG22) in Los Angeles.

The UK Biobank has enrolled half a million individuals and are "investigating the respective contributions of genetic predisposition and environmental exposure to the development of disease". Having begun in 2006, proteomics can greatly increase what can be discovered using this valuable resource. #ASHG22

Introduction to the hosts of the Proteomics in Proximity podcast, Dale Yuzuki, Cindy Lawley and Sarantis Chlamydas, with their respective backgrounds in academia and industry.

Brief introduction ("teaser") for the Olink podcast, Proteomics in Proximity.