Featuring a slide presentation and related discussion from Dr Sunnie Kim, including the following topics: Year in Review: Novel Treatments and Strategies in Gastroesophageal Cancer — Dr Kim (0:00) Case: A man in his mid 50s with poorly differentiated mismatch repair-deficient advanced gastric cancer receives first-line nivolumab/ipilimumab (49:22) Case: A man in his early 70s with HER2-positive gastroesophageal junction (GEJ) adenocarcinoma who experienced disease progression on...

Featuring perspectives from Prof Eric Van Cutsem, including the following topics: Immune Checkpoint Inhibitors in Localized Gastroesophageal (GE) Cancers  Introduction (0:00) Case: A man in his mid 50s with localized, poorly differentiated signet ring, mismatch repair-deficient advanced gastric adenocarcinoma — Sunnie Kim, MD (3:39) HER2-Positive GE Cancers Case: A man in his early 70s with HER2-positive gastroesophageal junction (GEJ) adenocarcinoma and disease progression on...

Featuring perspectives from Dr Ruben A Mesa, including the following topics: Introduction: Journal Club with Dr Mesa (0:00) Case: A woman in her mid 80s with an interesting and unusual presentation of primary myelofibrosis — Bhavana (Tina) Bhatnagar, DO (25:33) Case: A man in his early 70s, asymptomatic, with lower-risk primary MF (JAK2 V617F mutation) — Susannah Friemel, MD (29:42) Case: A woman in her early 80s with pancytopenia and palpable spleen who is diagnosed with primary MF —...

Featuring perspectives from Prof Nicoletta Colombo, Dr Matthew A Powell and Dr Brian M Slomovitz, moderated by Dr Shannon N Westin, including the following topics: Introduction (0:00) Current Approaches to First-Line Therapy for Advanced Endometrial Cancer (EC) — Prof Colombo (1:57) Novel Investigational Strategies for Newly Diagnosed EC — Dr Westin (25:35) Current Options for Relapsed/Refractory EC — Dr Slomovitz (45:57) Role of HER2-Targeted Therapy in the Management of Advanced EC — Dr...

Featuring perspectives from Dr Carlos M de Castro III, Prof Alexander Röth and Dr Ilene Ceil Weitz, including the following topics: Introduction: A Paroxysmal Nocturnal Hemoglobinuria (PNH) Audio Primer for General Medical Oncologists (0:00) Biology and Current Clinical Management of PNH (36:35) Future Directions in PNH Management (55:34) Tolerability and Other Practical Considerations with Available and Emerging Treatments for PNH (1:14:26) CME information and select publications

Featuring an interview with Dr Emmanuel S Antonarakis, including the following topics: Perspectives on advances in the management of prostate cancer over the last decade (0:00) Nonmetastatic high-risk prostate cancer and androgen deprivation therapy (ADT) intensification with abiraterone: Insights from the STAMPEDE trial (7:39) EMBARK: A Phase III trial of enzalutamide or placebo with leuprolide acetate and enzalutamide monotherapy for high-risk biochemically recurrent prostate cancer...

Featuring perspectives from Dr Naveen Pemmaraju, including the following topics: Recent developments in management approaches for myelofibrosis prior to ASH 2023 (0:00) Updated data with navitoclax in combination with ruxolitinib for patients with myelofibrosis (12:35) Key findings with pelabresib in combination with ruxolitinib for JAK inhibitor treatment-naïve myelofibrosis in the Phase III MANIFEST-2 study (22:21) Long-term follow-up from the Phase I/III XPORT-MF-034 trial of selinexor...

Featuring perspectives from Dr Andrew H Ko and Dr Eileen M O’Reilly, including the following topics. Selection and Sequencing of Therapy for Patients with Metastatic Pancreatic Adenocarcinoma (PAD) — Dr Ko (0:00) Biomarker-Based Strategies for Metastatic PAD; Novel Investigational Approaches — Dr O’Reilly (31:46) CME information and select publications

Featuring perspectives from Dr Kristen K Ciombor and Dr John Strickler, including the following topics. Select Biomarker-Directed Approaches for Colorectal Cancer (CRC) — Dr Ciombor (0:00) HER2-Targeted Approaches for Metastatic CRC (mCRC); Other Available and Emerging Therapeutic Strategies — Dr Strickler (25:17) CME information and select publications

Featuring perspectives from Dr Ghassan Abou-Alfa and Dr Richard S Finn, including the following topics. Introduction (0:00) Hepatocellular Carcinoma (HCC) — Dr Abou-Alfa (8:30) Biliary Tract Cancers (BTCs) — Dr Finn (33:16) CME information and select publications

Featuring perspectives from Dr Yelena Y Janjigian and Dr Samuel J Klempner, including the following topics. Current and Potential Role of Immune Checkpoint Inhibitors in the Treatment of Gastroesophageal Cancers — Dr Klempner (0:00) Other Available and Emerging Therapeutic Approaches — Dr Janjigian (31:42) CME information and select publications

Featuring perspectives from Dr Natalie S Callander and Dr Paul G Richardson, including the following topics. Introduction (0:00) Chimeric Antigen Receptor T-Cell Therapy, Bispecific Antibodies and Antibody-Drug Conjugates in Multiple Myeloma (MM) — Dr Callander (8:25) Integration of Other Novel Therapies into the Management of Newly Diagnosed and Relapsed/Refractory MM — Dr Richardson (31:52) CME information and select publications

Featuring perspectives from Dr Edward B Garon and Dr Corey J Langer, including the following topics. Role of Immune Checkpoint Inhibitors in Nonmetastatic Non-Small Cell Lung Cancer (NSCLC) — Dr Langer (0:00) Immune Checkpoint Inhibitors and Other Emerging Therapeutic Approaches for Metastatic NSCLC without a Targetable Tumor Mutation — Dr Garon (30:08) CME information and select publications

Featuring perspectives from Dr Ibiayi Dagogo-Jack and Dr Henela Yu, including the following topics. Management of Non-Small Cell Lung Cancer (NSCLC) with an EGFR Mutation — Dr Yu (0:00) Care of Individuals with Other Targetable Genomic Abnormalities — Dr Dagogo-Jack (31:01) CME information and select publications

Featuring perspectives from Dr Emmanuel S Antonarakis and Dr Rana R McKay, including the following topics. Role of Hormonal Therapy in Prostate Cancer (PC) Management — Dr McKay (0:00) Evidence-Based Use of Other Therapeutic Approaches — Dr Antonarakis (35:15) CME information and select publications

Featuring perspectives from Dr Matthew D Galsky and Dr Jonathan E Rosenberg, including the following topics. Introduction (0:00) Nonmetastatic Urothelial Bladder Cancer (UBC) — Dr Galsky (5:45) Metastatic UBC — Dr Rosenberg (31:51) CME information and select publications

Featuring perspectives from Dr Eric Jonasch and DR Brian Rini, including the following topics. Introduction (0:00) Current Management of Metastatic Clear Cell Renal Cell Carcinoma (RCC) — Dr Rini (5:11) Treatment Approaches for Nonmetastatic RCC; Optimal Care of Patients with Non-Clear Cell RCC — Dr Jonasch (38:52) CME information and select publications

Featuring perspectives from Dr Erika Hamilton, Dr Virginia Kaklamani and Dr Hope S Rugo, including the following topics. HER2-Positive Metastatic Breast Cancer — Dr Hamilton (0:00) Metastatic Triple-Negative Breast Cancer — Dr Rugo (29:06) SABCS® 2023 Review — Dr Kaklamani (45:20) CME information and select publications

Featuring perspectives from Dr Virginia Kaklamani, Dr Kevin Kalinsky and Dr Joyce O’Shaughnessy, including the following topics. Introduction (0:00) Localized HER2-Positive and Triple-Negative Breast Cancer — Dr O’Shaughnessy (1:52) SABCS® 2023 Review — Dr Kaklamani (31:48) Localized ER-Positive Breast Cancer — Dr Kalinsky (38:10) CME information and select publications

Featuring perspectives from Dr Bradley J Monk and Dr David M O’Malley, including the following topics. Introduction (0:00) Ovarian Cancer; Role of HER2-Directed Therapy in Gynecologic Cancers — Dr O’Malley (4:36) Endometrial Cancer and Cervical Cancer — Dr Monk (27:59) CME information and select publications

Featuring perspectives from Dr Ann S LaCasce, Dr Matthew Lunning, Dr Kami Maddocks and Dr Andrew D Zelenetz, including the following topics. Introduction (0:00) Follicular Lymphoma (FL) — Dr Zelenetz (2:29) Mantle Cell Lymphoma (MCL) — Dr Lunning (32:04) Hodgkin Lymphoma (HL) — Dr LaCasce (1:00:36) Diffuse Large B-Cell Lymphoma (DLBCL) — Dr Maddocks (1:18:53) CME information and select publications

Featuring perspectives from Dr Erika Hamilton, Dr Kevin Kalinsky, Dr Joyce O’Shaughnessy and Dr Hope S Rugo, including the following topics. Introduction (0:00) Optimal Integration of CDK4/6 Inhibitors into the Management of ER-Positive Metastatic Breast Cancer (mBC) — Dr O’Shaughnessy (5:46) Role of Oral Selective Estrogen Receptor Degraders (SERDs) in the Treatment of ER-Positive mBC — Dr Hamilton (43:06) Novel Strategies Targeting the PI3K/AKT/mTOR Signaling Pathway in ER-Positive mBC —...

Featuring perspectives from Dr Joyce F Liu, Dr Mansoor Raza Mirza and Dr David M O’Malley, moderated by Dr Kathleen N Moore, including the following topics: Introduction (0:00) Current Up-Front Treatment for Advanced Ovarian Cancer (OC) — Dr Liu (2:06) Potential Role of Immunotherapeutic Strategies for Advanced OC — Dr O’Malley (25:12) Incorporation of Novel Therapies into the Management of Relapsed/Refractory OC — Dr Moore (48:23) Diagnosis and Management of Adverse Events Associated with...

Featuring a slide presentation and related discussion from Dr Kanwal Raghav, including the following topics: Prevalence of HER2 alterations among patients with advanced gastrointestinal tumors beyond gastroesophageal cancer (0:00) Dual HER2 inhibition in the treatment of HER2-amplified colorectal cancer (CRC) (4:56) Efficacy and tolerability of the antibody-drug conjugate trastuzumab deruxtecan (T-DXd) for patients with HER2-expressing metastatic CRC (8:52) Activity and safety of the novel...