Predictive and Prognostic Biomarkers in Immunotherapy Moderator: Vamsi Velcheti, MD, Associate Professor, Director, Thoracic Oncology Program NYU Langone- Laura and Isaac Perlmutter Cancer Center, New York Faculty: Hossein Borghaei, DO, MS, Chief, Thoracic Medical Oncology, Co-Leader, Thoracic Cancer Service Line, Fox Chase Cancer Center, Philadelphia; and David Rimm, MD, PhD, Professor of Pathology and of Medicine (Medical Oncology); Director of Pathology Tissue Services; Director of Translational Pathology, Yale New Haven Hospital, New Haven
Citing the recent landmark tumor-agnostic approval of pembrolizumab for patients with microsatellite instability-high (MSI-H)/deficient DNA mismatch repair (dMMR) tumors and the approval of nivolumab/ipilimumab MSI-H/dMMR colorectal cancer, Vamsi Velcheti, MD, and Hossein Borghaei, DO, MS,...
Published 12/18/18
Vamsi Velcheti, MD, and David Rimm, MD, PhD, discuss the recent clinical trials that studied tumor mutation burden (TMB) as a biomarker and the mechanisms behind why tumors with high TMB respond to immunotherapy.
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Published 12/18/18