Chris and Jonathan speak to Dr. Swapnil Hiremath, a hypertension specialist and staff nephrologist at the Ottawa Hospital. As they discuss high blood pressure and how to treat it, they make their way to a highly contentious clinical trial, the Hygia trial, which allegedly compared two times of day when to take blood pressure medication. Its results are a little too perfect to be believed.   3:35 What is high blood pressure and what is “essential” hypertension? 8:34 The two numbers of blood pressure 10:45 How antihypertensive drugs work 13:38 How our body metabolizes a drug 17:30 The intense debate over when to take blood pressure medication 21:59 The contentious Hygia trial 32:47 Is the Hygia trial… the Hygia project? 35:02 Considering fraud 41:21 The best time to take medication 44:38 “One simple trick to reduce your risk of heart attacks by 60%!”   * Theme music: “Fall of the Ocean Queen“ by Joseph Hackl.   To contribute to The Body of Evidence, go to our Patreon page at: http://www.patreon.com/thebodyofevidence/.   Patrons get a bonus show on Patreon called “Digressions”! Check it out!     Links: 1) Swapnil Hiremath on Twitter: https://twitter.com/hswapnil 2) The nephrology journal club: https://www.nephjc.com/ 3) Swapnil Hiremath’s podcast: https://www.nephjc.com/freelyfiltered