Welcome to the third episode of The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we chat with Dr Kristiana Xhima and Professor Isabelle Aubert, lead and senior authors, respectively, of the article entitled: Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies. They discuss the exciting use of MRI-guided focussed ultrasound to improve blood-brain barrier penetration of a novel Alzheimer's disease therapeutic TrkA agonist.  Check out the full article on the Brain website: https://doi.org/10.1093/brain/awab460 This episode was hosted, edited and produced by Xin You Tai; co-hosted by Sarosh Irani; co-produced by Joanne Bell; original music by Ammar Al-Chalabi.