Welcome to the 17th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  This episode features a discussion with senior author Dr Bénédicte Ballanger of the Brain article entitled: Noradrenergic alterations in Parkinson’s disease: a combined 11C-yohimbine PET/neuromelanin MRI study Can this multi-modal study examining the role of Noradrenaline in Parkinson's disease offer insight into important neurotrasmitter pathophysiology and provide the...

Welcome to the 16th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  We are very excited to feature a January issue Brain article, where we speak with senior author Dr Lasse M Giil entitled:  Impaired glucose utilization in the brain of patients with delirium following hip fracture Delirium is a common condition with significant impact on patient outcome. This episode discussed potential intrinsic brain mechanisms that may underly...

Welcome to the 15th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  We are very excited to feature our first article from Brain Communications, where we speak with first author Dr Kiel Telesford of the article entitled: Neuron-binding antibody responses are associated with Black ethnicity in multiple sclerosis during natalizumab treatment This episode discussed racial differences in antibody response to natalizumab treatment for...

Welcome to the 14th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  In this episode we speak with Fu-Chin Liu, senior author of the article entitled: Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons.  This article explores a potential genetic basis for disordered speech by a mutation in the transcription factor FOXP2. This was discovered in KE family members with speech disturbances was a landmark...

Welcome to the 13th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  In this episode we speak with Josef Parvizi, senior author of the article entitled: Multisite thalamic recordings to characterize seizure propagation in the human brain This article explores the role of the thalamus in seizure propagation and how multi-site intracranial electrode recordings identify new and unexpected findings regarding which thalamic nuclei may have the...

Welcome to the 12th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  In this episode we speak with Nico Melzer, senior author of the article entitled: A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies This article explores expanding entity of GAD-65 associated neurological syndromes, the exciting role of T-cells and potential therapeutic avenues that these findings may bring.  Check out...

Welcome to the 11th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications.  In this episode we speak with Ted Price, senior author of the article entitled: RNA profiling of human dorsal root ganglia (DRG) reveals sex differences in mechanisms promoting neuropathic pain This article explores exciting findings around differences in the DRG transcriptome which were only apparent when stratifying participants by sex and how these differences may...

Welcome to the 11th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we speak with Philip Insel, lead author of the article entitled: Tau positron emission tomography in preclinical Alzheimer’s disease The article explores the utility of tau PET imaging in three independent, large cohorts of cognitively normal individuals with high levels of amyloid (on PET imaging). We discuss specific areas of the brain with high tau...

Welcome to the 10th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we speak with Hideaki Nishihara and Britta Engelhardt, lead authors of the article entitled: Intrinsic blood–brain barrier dysfunction contributes to multiple sclerosis pathogenesis This was a transcontinental recording with our guests dialing in from Japan and Europe. The article explores blood-brain barrier dysfunction as a pathogenic process of multiple...

Welcome to the 9th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we chat with Professor Robyn S. Klein, senior author of the article entitled: COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis This article explores the ongoing challenge to better understand the mechanisms underlying the cognitive and neuropsychiatric sequlae of the Sars-CoV2 infection. We discuss the use of both animal model...

Welcome to another episode of The Brain Podcast (first for 2023!) - the official podcast for the journal Brain and sister journal Brain Communications. In this episode, three guests joined us to discuss the article entitled: Gene variant effects across sodium channelopathies predict function and guide precision therapy. Professor Andreas Brunklaus (first author) and Professor Stephanie Schorge (senior author) discuss their fascinating data-driven approach to better understand how mutations...

Welcome to the seventh episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we chat with Dr Nina M Rzechorzek, lead author of the article entitled: A daily temperature rhythm in the human brain predicts survival after brain injury We discuss how brain temperature was measured using invasive and non-invasive methods to identify a physiological daily rhythmicity. The loss of this brain rhythm was strongly predictive of survival in...

Welcome to The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we are joined by Professor Soon-Tae Lee to discuss his review article entitled Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes. Read the full article on the Brain website: https://doi.org/10.1093/brain/awac166 Maarten Titulaer and Robin van Steenhoven wrote an excellent commentary on the article...

Welcome to The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we are joined by Associate Professor Pavan Bhargava to discuss his review article entitled  The contribution of B cells to the cortical damage in multiple sclerosis.  Read the full article on the Brain website: https://doi.org/10.1093/brain/awac233 This episode was hosted, edited and produced by Xin You Tai; co-hosted by Sarosh Irani; co-produced by Joanne...

Welcome to The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we chat with Dr Georgia Melli, senior author of the article entitled: Tau protein quantification in skin biopsies differentiates tauopathies from alpha-synucleinopathies She discusses the use of skin biopsy to quantify pathological tau protein as an accessible and useful clinical tool in the diagnosis of neurodegenerative diseases.   Check out the full article...

Welcome to the third episode of The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. In this episode we chat with Dr Kristiana Xhima and Professor Isabelle Aubert, lead and senior authors, respectively, of the article entitled: Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies. They discuss the exciting use of MRI-guided focussed ultrasound to improve blood-brain barrier penetration of a novel...

Welcome to another episode of The Brain Podcast - the official podcast for the journal Brain and sister journal Brain Communications. We are joined by Professor Marsel Mesulam who will discuss his masterclass in clinico-pathological-neuroimaging analysis of primary progressive aphasias.  Check out the full article on the Brain website: https://doi.org/10.1093/brain/awab410 This episode was hosted, edited and produced by Xin You Tai; co-hosted by Sarosh Irani; co-produced by Joanne Bell;...

Welcome to the first episode of the Brain podcast- the official podcast for the journal Brain and sister journal Brain Communications. We are joined by Professor Roland Liblau who will tell us about his group's mouse model of narcolepsy in which autoimmune inflammation of orexinergic neurons is induced by influenza vaccination. Check out the full article on the Brain website: https://academic.oup.com/brain/article-abstract/145/6/2018/6581499 This episode was hosted, edited and produced by...