Welcome to the 11th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. In this episode we speak with Philip Insel, lead author of the article entitled: Tau positron emission tomography in preclinical Alzheimer’s disease The article explores the utility of tau PET imaging in three independent, large cohorts of cognitively normal individuals with high levels of amyloid (on PET imaging). We discuss specific areas of the brain with high tau concentration and how this differs from the traditional Braak model from neuropathology data. Philip also details how tau PET imaging can play a role in clinical trials.  Additionally, we welcome Dr Adam Handel onto the team as a new podcast co-host for this episode and many more to come! Check out the full article on the Brain website: https://doi.org/10.1093/brain/awac299 This episode was co-hosted, edited and produced by Xin You Tai; co-hosted by Adam Handel; co-produced by Joanne Bell and Sarosh Irani; original music by Ammar Al-Chalabi.