Welcome to another episode of The Brain Podcast (first for 2023!) - the official podcast for the journal Brain and sister journal Brain Communications. In this episode, three guests joined us to discuss the article entitled: Gene variant effects across sodium channelopathies predict function and guide precision therapy. Professor Andreas Brunklaus (first author) and Professor Stephanie Schorge (senior author) discuss their fascinating data-driven approach to better understand how mutations in sodium channels affect function with potential for precision therapy. We were fortunate to also e joined by Professor Massimo Mantegazza, who provided additional expert opinion.  Enjoy this rich, in-depth discussion!  Check out the full article on the Brain website: https://doi.org/10.1093/brain/awac006 This episode was hosted, edited and produced by Xin You Tai; co-hosted by Professor Sarosh Irani; co-produced by Joanne Bell; original music by Ammar Al-Chalabi.