Imagine if, as a teenager, you were told that you would lose your vision over the course of a few decades. How would you approach your life, your world, and the people in it? Joining us to discuss these questions is writer Andrew Leland. Andrew has retinitis pigmentosa, a condition that affects the retina's ability to respond to light, leading to progressive irreversible vision loss. Andrew's works have appeared in The New York Times Magazine, The New Yorker, and elsewhere, and he is the...

For many people, the idea of politics in healthcare conjures up hyperpartisanship, where power and party loyalty trump public interest. But Joshua Sharfstein, MD is passionate about politics and health care because to him, these are opportunities to bring together wide-ranging expertise and navigate seemingly irreconcilable interests to implement changes that change the lives of millions. Dr. Sharfstein has led a career reflective of this passion. He has served as the Secretary of the...

Addiction and substance use disorders have long been mired in misconception and stigma, seen as moral failings or a lack of willpower. But the reality is far more complex and nuanced. In this episode, we are joined by Dr. Nzinga Harrison, a psychiatrist and addiction medicine specialist who is the co-founder of Eleanor Health, a tech-enabled provider of comprehensive and longitudinal care for substance use disorder and mental health. Dr. Harrison holds a faculty appointment at the Morehouse...

Moral imagination is the ability to transcend one's own immediate context and experiences to explore diverse moral perspectives and ethical scenarios. In medicine, where decisions can reverberate profoundly through a patient’s life, moral imagination allows us to navigate the ethical complexities of particular situations while honoring the dignity of others. But how can this capacity be developed? Can we actually teach moral imagination to clinicians? In this episode, we are joined by Dr....

What is the intersection between psychotherapy and Buddhism? For decades, Mark Epstein, MD, a practicing Buddhist and psychiatrist, has deeply explored how Buddhist philosophy can be integrated into therapy to help patients heal from trauma. His key insight is that Buddhism grants us the wisdom to reshape our relationships with our personal stories, through which we conceptualize and contextualize our emotions and identities. Dr. Epstein is the author of Thoughts Without a Thinker, The Trauma...

Despite advances in medicine, issues in women's health are still often mired in stigma, shame, misinformation, and disparities in access and societal standards. In this episode, we are joined by Jen Gunter, MD, who is perhaps the most well-known and outspoken gynecologist in the world. She has made it her life's work to dispel potentially dangerous myths about women's health and, more broadly, the wellness industry. Dr. Gunter is the author of The Preemie Primer, The Vagina Bible, Menopause...

In many ways, emergency rooms are the frontlines of health care, serving as the initial point of contact for people experiencing sudden and severe health problems or accidents. In other ways, emergency rooms are the last line of defense, serving as a critical catch-all for vulnerable populations who have nowhere else to go. How can doctors reconcile the tension between the desire to help others with the frustrating inability to address the many systemic causes of health problems encountered...

When we gaze at the stars and wonder at our place amid the expanse of the universe, or when we witness the birth of a child and marvel at the miracle of existence itself, or when we listen to music that seems to touch our soul — there are moments in life when we feel a transcendent connection to things larger than ourselves. But how are we to make sense of these experiences in the age of science? In perhaps our most meditative episode yet, we speak with Alan Lightman, PhD, a theoretical...

Multiple sclerosis is the most common disabling neurological disease among young adults. It's a disease in which the body's immune system begins attacking the protective covering around nerve cells, leading to a wide variety of symptoms, ranging from vision problems to difficulty walking fatigue to dizziness to speech problems. Our guest on this episode, neurologist Stephen Hauser, MD, has led research that has been key to developing our understanding of this disease, and his work has...

According to emergency physician Leana Wen, MD, MS, "public health saved your life today, you just don't know it." Having been appointed the Baltimore City Health Commissioner at the age of 31, she certainly has the credentials and stories to illustrate this assertion. Prior to the COVID-19 pandemic, public health played a frequently misunderstood and under-appreciated role in our society, ranging from sanitation and immunization to mental health support and pollution control. In addition to...

Storytelling is the oldest medical technology — so claims our guests on this episode, Laurel Braitman, PhD, an acclaimed author and Writer-in-Residence at Stanford School of Medicine. Laurel offers a uniquely qualified perspective on the matter, having grown up in a medical family and now mentoring clinicians everywhere to help them fulfill their writing goals. She received her doctorate in History and Anthropology of Science from MIT, and her most recent work is a 2023 memoir titled What...

When professor of English literature Theresa Brown, PhD, BSN, RN decided to become an oncology nurse, she suddenly found herself juggling seemingly-impossible patient expectations. And when she later was diagnosed with breast cancer herself, she was forced to confront the paradoxes of a healthcare system that demands so much of its practitioners yet provides insufficient support for them. She recounts these revelations in her recent book, Healing: When a Nurse Becomes a Patient. A frequent...

Despite the optimism of modern healthcare promising ever more miraculous cures, there are inevitably moments in medicine that compel us to face the fact that not all problems can be fixed. Recognizing the limits of medicine and navigating the space between what can be done and what should be done for a patient requires a fundamental shift in mindset, one imbued with an understanding that sometimes acceptance is the most compassionate response. Our guest on this episode, palliative care...

As a medical student, former college quarterback David Fajgenbaum, MD was at the peak of his health and physique when he suddenly came down with a mysterious disease that, within weeks, led to multiple organ system failure. Dr. Fajgenbaum found himself on the brink of death over and over again in the intensive care unit, at one point receiving his last rites, with all of his doctors baffled about the cause of his illness. When the culprit was eventually found to be Castleman Disease, a rare...

According to our guest on this episode, Gail Gazelle, MD, there has never been a more difficult time to be a doctor. Whether or not you agree with this statement, it's true that clinicians today are expected to see more patients in less time than ever before, spend hours on the electronic medical record, and manage countless administrative and organizational pressures. Dr. Gazelle is a physician coach who specializes in helping doctors build resilience and confidence in order to overcome...

"All dying is a spiritual process," says our guest on this episode, hospice chaplain Kerry Egan. By this, she means that each person's death is more than just a biological event; it's an opportunity to reflect on the culmination of our human experiences, the lessons we’ve learned, and the impact we've had on others. The recognition of our impermanence prompts us to grapple with questions of legacy and purpose, infusing our mortal existence with depth and significance. Over the course of our...

A lung transplant—taking some or all of one person's lungs and putting them into someone else, giving the recipient years of additional life—sounds nothing short of miraculous. Today, over 2500 lung transplants are performed every year in the US. Still, it's among the most medically and ethically complex areas of medicine. Joining us in this episode is David Weill, MD, former director of the Lung and Heart-Lung Transplant Center at Stanford Health Care. He is also the author of Exhale: Hope,...

It’s no longer a surprise that the race and ethnicity of a patient influence their health outcomes. But back in the 1990s, when Lisa Cooper, MD first documented and published findings that supported the role of patient race on the quality of physician-patient interactions, these were groundbreaking, even radical ideas. Today, Dr. Cooper, a physician and social epidemiologist, is the Director of the Johns Hopkins Center for Health Equity and a Bloomberg Distinguished professor at the Johns...

Though often invisible in our society, studies have shown that more than seven out of ten people experience trauma at some point in their lives, whether it's physical, sexual, or emotional abuse or a life-threatening accident or illness. In this episode, we speak with Bessel van der Kolk, MD, a psychiatrist and pioneering researcher on post-traumatic stress. His 2014 book, The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma, spent 27 weeks at the top of the New York Times...

We live in a culture that vilifies stress. Stress, we are told, is unhealthy both physiologically and emotionally, and something to be avoided at all costs. But Stanford University health psychologist Kelly McGonigal, PhD believes that by suppressing or ignoring it, we're missing out on the benefits of effective stress management. Kelly is also a bestselling author whose work focuses on the mind-body connection and the psychology of compassion and mindfulness. In this episode, Kelly shares...

For over 50 years, the National Eye Institute (NEI) has been a driving force for cutting-edge vision research, education, and public health guidance. In this episode, we speak with Dr. Michael F. Chiang, Director of the NEI. A pediatric ophthalmologist by training, Dr. Chiang's work focuses on the application of biomedical informatics to ophthalmology, in areas ranging from telehealth to artificial intelligence to health data management. Over the course of our conversation, Dr. Chiang...

Awe is a feeling we've all experienced but often struggle to articulate. Whether it's the sheer scale of a skyscraper, the infinite expanse of a starry night sky, or the miracle of childbirth, moments of awe can strike us at unexpected times, leaving us speechless, inspired, and even profoundly transformed. In this episode, we speak with Dacher Keltner, PhD, a psychologist at UC Berkeley, where he is the founding director of the Greater Good Science Center and the host of The Science of...

First used in the context of Vietnam war veterans, the term "moral injury" refers to the psychosocial, behavioral, and spiritual distress that comes from perpetuating or witnessing events that contradict deeply held moral beliefs. In recent years, moral injury has increasingly been used to describe one of the main challenges clinicians face in modern medicine — the challenge of knowing what care patients need but being unable to provide it due to constraints beyond the clinicians control,...

When COVID-19 rapidly emerged, the World Health Organization (WHO) was thrust into an unprecedented challenge. The global pandemic response was in disarray; health care resources were limited and inequitably distributed; and misinformation burgeoned. At the center of this maelstrom was Dr. Soumya Swaminathan, who served as the WHO’s first Chief Scientist, from 2019 until 2022. Dr. Swaminathan not only spearheaded efforts to disseminate the latest scientific findings about the coronavirus and...

Navigating the unforgiving hours and ethical challenges of medical training while holding onto humanism; the medical and cultural history of the human heart; the moving journey of a doctor as he wrestles with his duties as a son and caregiver for a father with dementia. These are just some of the diverse subject matters our guest in this episode, Dr. Sandeep Jauhar, has written about. Dr. Jauhar is the director of the Heart Failure Program at Long Island Jewish Medical Center and a...