Dean Lloyd Minor welcomes Patrick Collison, co-founder and CEO of the e-commerce company Stripe, for a conversation about his journey as an entrepreneur in tech and biomedical science. They explore the origins of his e-commerce monolith, how he keeps Stripe a reliable mainstay for businesses around the world, and why he established the Arc Institute in the midst of a pandemic to accelerate biomedical research.  They also discuss the value of continuous improvement in leadership, the importance of understanding generational differences in the workforce, and the critical need to keep expanding the global knowledge base for the greater good.