In a special episode recorded in front of a live audience, Dean Lloyd Minor welcomes Chelsea Clinton, a bestselling author and an advocate for public health and early childhood education. They discuss the importance of accountability for scaling global health initiatives, and the power of storytelling to counter misinformation in science and health. They also talk about finding motivation through conscious optimism and rebuilding public trust through support of individuals, families, and communities. Along the way, they share memories of Chelsea’s time as a Stanford undergraduate and their overlapping memories of their home state of Arkansas.