This month, Jack and Shobita talk about the challenges of ensuring that AI and gene editing reflect human values, and reflect on what the recent train derailment in East Palestine, Ohio tells us about the politics of knowledge. And they chat with Amy Moran-Thomas, Associate Professor of Anthropology at MIT, about her clarion call to address the racial biases embedded in the pulse oximeter, at the height of the COVID-19 pandemic in August 2020.