Fever is an incredibly effective mechanism to fight off pathogens. Clearly, whilst many illnesses that cause a fever don’t require anything more than the body’s natural response, there are some patients in which a fever might represent a serious illness. Differentiating those serious illnesses from self-limiting presentations can be tricky at times, but can also be anxiety provoking for clinicians and parents, or carers of that child.  In children the limited communication can make the diagnostic challenge of the origin of the fever a real challenge, along with the added difficult of gaining some tests. Differentiating those with a benign disease from those with a life threatening presentation can be a daunting challenge. The numbers of presentations to healthcare providers are staggering. Paediatric fever has been reported to represent as high as 15-25% of all presentations in primary care and emergency departments, so massive numbers. Thankfully the prevalence of serious infections in children is low and is estimated at So we thought with this common but tricky presentation that it was about time we tackled the topic. We'll be running through; A definition Patholphysiology Relevance of the severity of the fever Febrile seizures Clinical assessment NICE guidelines Duration of fever Management Antipyretics Once again we’d love to hear any thoughts or feedback either on the website or via X @TheResusRoom! Simon, Rob & James