As the Golub Family Professor of stem cell and regenerative biology at Harvard University, Paola Arlotta seeks to understand how the human brain is formed and what makes it unique. After being inspired by her high school science teacher, Antonio Vecchia, Arlotta pursued a research path that led to her current work exploring the cerebral cortex by growing human organoids in 3D cell culture and investigating their development with single cell sequencing techniques. In this Science Philosophy in...

Researchers tackle the antibiotic resistance crisis with explainable neural networks and high throughput drug discovery.

The field of psychedelics research has exploded in recent years, as scientists dig deeper into the neuroscience and pharmacology of hallucinogens and how their unique properties can be harnessed to understand and treat depression, anxiety, post-traumatic stress disorder, Alzheimer’s disease, dementia, and neurodegenerative diseases. Remarkably, the human body produces its own endogenous psychedelics, the reasons for which have implications for understanding the ordinary and extraordinary...

Jonathan Weissman and Luke Gilbert share how they developed several CRISPR-based epigenetic editors and how these tools differ from traditional CRISPR.

Scientists discuss the advent of robotically run research and the new era of academic cloud labs on the horizon.

Researchers apply the principles of synthetic biology to address some of the most pressing human health challenges. In what some consider a science and an artform, scientists use bacterial components in creative ways to create synthetic cells for cancer research. In this episode, Iris Kulbatski from The Scientist’s Creative Services Team spoke with Kate Adamala, an assistant professor at the University of Minnesota and a synthetic biologist working on engineering synthetic cells, to learn...

Neurobiologists, computer scientists, and engineers join forces to grow mini brains using automation and make their technologies smarter with artificial intelligence.

Fecal transplantation is an established procedure for controlling recurrent Clostridium difficile infection by replenishing healthy bacteria in the gut. Researchers explore novel applications of fecal transplantation for treating other conditions, including psychiatric disorders. In this episode, Iris Kulbatski from The Scientist’s Creative Services Team spoke with Ian Carroll, an assistant professor in the Department of Nutrition at the University of North Carolina at Chapel Hill, and Kylie...

Xitiz Chamling is an assistant professor of ophthalmology at Johns Hopkins University School of Medicine. From vision research to the pursuit of multiple sclerosis treatments, his philosophy of science centers human-based systems to study the neuroprotective layer called myelin, which surrounds and insulates nerves cells. In this episode, Deanna MacNeil from The Scientist’s Creative Services Team spoke with Chamling to learn more about his latest work combining stem cell and CRISPR-Cas9...

Through a combination of basic science research and clinical trials, researchers uncover innovative approaches for targeted cancer treatment.

Jie Sun shares how his curiosity, creativity, and motivation to address clinical public health needs steer his research in immunology and infectious disease.

David Liu shares how integrating chemistry and evolution in his research has directed his work on base editing techniques aimed at developing new therapeutics.

Claire Higgins is reader in the department of bioengineering at Imperial College London. Her philosophy of science involves a problem-solving approach to research, where she models tissue growth, development, and repair using human skin and hair follicles. In their latest work, her research team transplanted hair follicles into human skin scars in an attempt to make that tissue healthy again. In this episode, Iris Kulbatski from The Scientist’s Creative Services Team spoke with Higgins to...

Scientists often refer to DNA as the blueprint of a cell. Whether the genetic material is single stranded or double stranded, linear or circular, organisms across the tree of life rely on their genomic blueprint for instructions on living, growing, and reproducing. Due to the amount of information carried by this blueprint, the size of the genome poses a biological dilemma; from humans to single-celled aquatic organisms, all eukaryotes must find a solution for organizing their DNA into a tiny...

Most mammals communicate vocally but humans are unique in their ability to communicate using spoken language. Humans are not born with an innate capacity to speak and understand language, but rather learn this skill as the brain develops. The complex interplay between neurobiology, genetics, and the environment shape vocal learning, but scientists do not understand the full extent to which each of these contribute to language development or to speech and language disorders. A recent study by...

Neurodegenerative disorders progressively impair a patient’s ability to function. Scientists expect the prevalence of these conditions to increase as the world’s population ages, and their clinical, genetic, and pathological heterogeneity complicates disease diagnosis and prognosis. The link between the immune system and neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) is becoming clearer thanks to improvements in immune cell profiling. A recent study by a team of ALS...

Jennifer Munson is an associate professor in the Department of Biomedical Engineering and Mechanics at Virginia Tech. Her overarching research goal is to find new therapeutic targets in the tumor microenvironment by examining cancer from an onco-engineering perspective. Munson’s work combines fluid mechanics, neuroengineering, tissue engineering, and translational cancer research. She creates personalized models of brain and breast cancer with patient-derived cells to examine the roles of...

Jukka Koskela, a senior researcher at the Finnish Institute for Molecular Medicine, studies the complex genetics of various diseases, including rare diseases such as pulmonary fibrosis. Koskela began pursuing research as a requirement of his clinical training at Helsinki University Central Hospital, and through discussions shared with other scientists, he became passionate about seeking genomic avenues for personalized disease risk assessment. In this episode, Deanna MacNeil from The...

Despite the genetic basis of healthy aging, diet plays an important role in preventing inflammation, diabetes, and cognitive decline. Yet, healthy food choices are just part of the equation. Researchers are discovering how fasting can undo some of the metabolic damage imposed by the overindulgences of the typical Western diet. The human body may be wired to function optimally when exposed to periods of fasting, which reawakens stem cell activity and the body’s intrinsic capacity to...

Paul George, an assistant professor of neurology and neurological sciences at Stanford University, taps into the bioelectrical language of the injured brain to reawaken the healing potential of neural stem cells. Inspired by his patients, he looks for innovative strategies that may one day help patients recover from neurodegenerative diseases such as stroke. In this episode, Iris Kulbatski from The Scientist’s Creative Services Team spoke with George to learn more about what being a scientist...

As humans age, cells often acquire defects that lead to cancer. However, this fate may not be set in stone, as certain animals can circumvent the ravages of time and keep their cells healthy. In this episode, Niki Spahich from The Scientist’s Creative Services Team spoke with Vera Gorbunova, professor of biology at the University of Rochester and co-director of the Rochester Aging Research Center, to learn about her research on naked and blind mole-rat cancer resistance.   The Scientist...

To regulate protein production, cells use sophisticated strategies to keep RNA levels in check. This balance is especially important for hormone production, particularly aldosterone—the master regulator of blood pressure. When this balance is disrupted, the risk for disorders including hypertension and cardiovascular disease increases. In this episode, Niki Spahich from The Scientist’s Creative Services Team spoke with Neelanjan Mukherjee, assistant professor of biochemistry and molecular...

Welcome to Science Philosophy in a Flash, a mini podcast series produced by The Scientist’s Creative Services Team. In this series, we highlight researchers’ unique outlooks on what it means to be a scientist. Andrew Pelling, a professor at the University of Ottawa with appointments in the Departments of Physics and Biology, has a fresh approach to practicing science. He uses fruits and vegetables to create biodegradable scaffolds for tissue regeneration. His lab is a cross-pollinating hive...

Sequencing the human genome in the early 2000s was an incredible feat, but the sequence was incomplete. Recently, a consortium of researchers published a telomere-to-telomere assembly of a complete human X chromosome. This accomplishment was made possible by advances in sequencing technology, allowing researchers to address the previous technical difficulties in analyzing challenging genomic regions. Filling in these gaps of the human genome represents a breakthrough in human genetics and...