Gut Immune Body Brain Axis. Dr Gundry: Leaky Gut, gut microbiome and diet Renowned Cardiovascular Surgeon who realised that all he was doing was treating the symptoms so he studied the underlying causes. The lining of the gut is one cell thick As bacteria break down the gut that is when ageing starts Ibuprofen or roundup disastrous the bacteria population Skin is a mirror of the lining of the gut Joints do not naturally wear out. Animal model C Elegans as bacteria begin to break down the wall of the gut that is when ageing starts 105 year old people have a diverse set of bugs identical to a healthy 30 year old. It is not attacking the wall of the gut. Ecermansia musinophilia. Lives in the mucous layer whose job is to trap lectins plant proteins looking for sugar molecules and to protect the wall of the gut from harmful bacteria. Ecermansia musinophilia eats mucus which in turn makes more mucus. Metformin works by increasing mucous and this change in bacteria makes some people have mild diarrhoea as the bacteria change. If we damage this lining eg ibuprofen or food with roundup destroys the bacteria population and gut lining. Glyocosade an antibacterial damages Ecermansia Musinophilia even though it does not directly affect human cells. Antibiotics in food or direct prescription eg ladies who take low dose for UTI have a higher incidence of heart disease. Heart disease is an autoimmune disease starting in the gut. Cholesterol is an innocent bystander which gets sucked into the inflamed wall of a blood vessel. Infants with heart transplants have coronary artery disease with pathology identical with typical coronary artery disease. Lectins which are a foreign protein which can stick to sugar molecules on the surface of blood vessels are the cause of atherosclerosis and removing lectins reduces those markers. Lectins are one of the plant defence systems. Sticky proteins that look for specific sugar molecules to stick to which insights an inflammtory response. Joints do not normally wear out. Usually you can find bacterial particles in the joint fluid of arthritis Because Lectins broke down the wall of the gut. 65% of the immune system is behind the wall of the gut because the gut is where the outside word gets through. A reason why we store fat in the gut is to provide energy to the immune system. Similarly fat on the outside of atherosclerotcic blood vessles correlates with the severity of inflammation. Fat is not the cause . It is there because of the inflammation and the inflammation is there due to the leaky gut. The immune system responds to antigens on bacteria of viruses. Lectins have antigens with cross reactivity with other proteins in the body. Eg thyroid. Nightshade vegetables or peanuts Lectins disrupt the microbiome and break up the lining of the gut allowing entry by lectins and by bacteria or bacterial particles. Hence if you inject a bacterial lipopolysaccharide into a person you can induce septic shock. Alzheimers Parkinsons is neuroinflammation. Most amyloid is produced by bacteria in the gut. Therefore 40 billion dollars invested in antiamyloid drugs has been a waste because amyloid is produced by the amyloid producing bacteria inthe gut fet by western diet. Then the amyloid has to get through the wall of the gut. Once they get through the gut wall and goto the brain it will produce more amyloid. Cholesterol and amyloid coexist in dementia in those with the apoE gene. The apo E gene codes for a carrier molecule because it is less efficient at transporting cholesterol. It cannot get out of the cell after it has been attracted by inflammation. Faecal microbial transplant: 1970s broad spectrum antibiotics came out which made...