In a wide-ranging conversation, Leo Laporte talks with Dr. George Church about the history and future of genome sequencing. Dr. Church explains why he is very excited about how they made an organism resistant to all viruses- both known and unknown.   They also talk about:  How Dr. Church made sequencing affordable (from $3BN to $600) Where are we on sequencing the entire human genome, and why would we even want to? How close are we to reversing aging? Should we use gene therapy to...

New York Times bestselling author Daniel Suarez returns to talk with Leo Laporte about the second book in his 'Delta-v' novel series, 'Critical Mass,' where a group of pioneering astropreneurs must overcome never-before-attempted engineering challenges to rescue colleagues stranded at a distant asteroid—kicking off a new space race in which Earth's climate crisis could well hang in the balance.  Get 'Critical Mass': https://amzn.to/3Yjb9xu Host: Leo Laporte Guest: Daniel Suarez ...

Writer/activist Cory Doctorow and scholar Rebecca Giblin join Leo Laporte to talk about their latest book Chokepoint Capitalism: How Big Tech and Big Content Captured Creative Labor Markets and How We'll Win Them Back. They argue that we're in a new era of "chokepoint capitalism," with exploitative businesses creating insurmountable barriers to competition that enable them to capture value that should rightfully go to others. Get "Chokepoint Capitalism": https://chokepointcapitalism.com ...

Tripp Mickle joins Leo Laporte to discuss his new book, "After Steve: How Apple Became a Trillion-Dollar Company and Lost Its Soul". They discuss the shift in Apple's dynamic and approach to products after the passing of Steve Jobs from a company of innovation with Jony Ive, to a company of efficiency under Tim Cook. Host: Leo Laporte Guest: Tripp Mickle Download or subscribe to this show at https://twit.tv/shows/triangulation.

Amy Webb joins Leo Laporte to discuss her new book, "The Genesis Machine." Webb explains synthetic biology, tells the story of golden rice, and shares a glimpse of the future and the changes we can expect. Get "The Genesis Machine": https://amzn.to/3BC7K2t Host: Leo Laporte Guest: Amy Webb Download or subscribe to this show at https://twit.tv/shows/triangulation.

Leo Laporte interviews Andy Weir, author of "The Martian," about his new book, "Project Hail Mary." The discussion starts out spoiler-free with a chat about making the book into a film, how Andy Weir approached writing this book, and the time he confused Ryan Reynolds and Ryan Gosling. After a loud and apparent spoiler warning (at 32:04), the two continue their chat by discussing "Project Hail Mary" in depth. Weir shares a bit about the science behind the book, the characters he's created,...

Jason Howell is joined by TWiT's studio engineer to talk about his time as the drummer and founder of the progressive rock band Cairo, creating the Virtual Live Show, and how the intersection of music and tech has evolved. Cairo on YouTube: https://www.youtube.com/JeffBrockmanDirector Virtual Live Show on Twitter: https://twitter.com/virtualliveshow Host: Jason Howell Guest: Jeff Brockman Download or subscribe to this show at https://twit.tv/shows/triangulation.

Flynn Coleman, writer, and international human rights attorney, joins Denise Howell to talk about her book A Human Algorithm: How Artificial Intelligence Is Redefining Who We Are. Flynn argues that we must instill values, ethics, and morals into our robots, algorithms, and other forms of AI by developing and implement laws, policies, and oversight mechanisms to protect us from tech's insidious threats. Get "A Human Algorithm": https://amzn.to/2rIqgH6 Host: Denise Howell Guest: Flynn...

Stephen Wolfram is a computer scientist who designed Mathematica, Wolfram Alpha, and the Wolfram Language. He talks to Mikah Sargent about translating between human language, mathematics, and programming languages, how computational language works, and how he has spent his life trying to build computational intelligence up. Host: Mikah Sargent Guest: Stephen Wolfram Download or subscribe to this show at...

Margaret O'Mara, Professor of History at the University of Washington, joins Mikah Sargent to talk about her book The Code: Silicon Valley and the Remaking of America. They dive into the behind-the-scenes history of Silicon Valley, including how the Cold War shaped what Stanford University is today, shine a light on some of the unsung heroes like Ann Hardy and David Morgenthaler, and the legacy of Steve Jobs. Get "The Code": https://amzn.to/32ozIwm Host: Mikah Sargent Guest: Margaret...

Scott Petry is the CEO of Authentic8. He talks to Leo Laporte about his work on the Newton, how he saved the world from spam, and his plan to make your browser safe. Host: Leo Laporte Guest: Scott Petry Download or subscribe to this show at https://twit.tv/shows/triangulation.

Brett Frischmann is the Charles Widger Endowed University Professor in Law, Business and Economics, Villanova University and joins Denise Howell to discuss his book, co-authored with Evan Selinger, 'Re-Engineering Humanity.' They talk about what's happening to our lives as society embraces big data, predictive analytics, and smart environments. Host: Denise Howell Guest: Brett Frischmann Download or subscribe to this show at...

Famed writer, comedian, and actor John Hodgman (though not nearly as those two corgis from Instagram) returns to join Mikah Sargent to discuss his latest book Medallion Status: True Stories from Secret Rooms. They examine status, fame, and identity; and dive into how to make the perfect hard-boiled egg, how a nude scene with an oboe relates to vulnerability, and how celebrity has evolved. Get "Medallion Status": https://amzn.to/36picuc Host: Mikah Sargent Guest: John Hodgman Download...

Yancey Strickler is the co-founder and former CEO of Kickstarter and joins Jason Howell to talk about his new book, This Could Be Our Future: A Manifesto for a More Generous World. They discuss the crowdfunding platform's transition into a public-benefit corporation, leading to Yancey's book, which details a philosophy and framework for building a society that looks beyond "financial maximization" and more towards other values like community, purpose, and sustainability. Buy "This Could Be...

Jeri Ellsworth returns to talk with Jason Howell about Tilt Five's holographic tabletop gaming system, what happened with her previous augmented reality startup castAR, and the how the AR/VR space has evolved and where it's going. Tilt Five on Kickstarter: http://twit.to/tiltfive Host: Jason Howell Guest: Jeri Ellsworth Download or subscribe to this show at https://twit.tv/shows/triangulation.

Ruha Benjamin, Associate Professor of African American Studies at Princeton University, joins Mikah Sargent to talk about her new book 'Race After Technology: Abolitionist Tools for the New Jim Code.' They discuss how emerging technologies can reinforce and amplify racial biases and ways we could solve this problem. Host: Mikah Sargent Guest: Ruha Benjamin Download or subscribe to this show at https://twit.tv/shows/triangulation.

Mikah Sargent talks with professor Kate O'Neill about her new book, 'Waste' and what we can do about the ever-growing amount of trash each of us produces. They discuss what happens to much of our e-waste and how tech companies could work proactively, including the right-to-repair. One big issue is how China changed recycling world-wide, complicating the recycling industry and what happens next. Some solutions to this problem include finding alternatives to plastic and developing a global...

Best known for developing the sleep-aid app White Noise, Todd Moore is an app developer, founder and CEO of TMSOFT, and author of Tap, Move, Shake. Todd joins Ant Pruitt to discuss his advice for app devs, the differences in developing for iOS and Android, and working on new platforms like AR/VR and virtual assistants. Get White Noise: https://www.tmsoft.com/white-noise/ Buy "Tap, Move, Shake": https://amzn.to/2nPfyw4 Host: Ant Pruitt Guest: Todd Moore Download or subscribe to this...

Shel Israel is a writer, consultant, and expert on how technology is shaping humanity. He talks with Denise Howell about how the development of Artificial Intelligence is affecting driving, education, and even dentistry. Host: Denise Howell Guest: Shel Israel Download or subscribe to this show at https://twit.tv/shows/triangulation. Sponsor: ZipRecruiter.com/triangulation

Jono Bacon is the author of 'People Powered: How Communities can Supercharge your Business, Brand, and Teams.' He talks with Leo Laporte about how to grow your community by facilitating safe, constructive feedback. Host: Leo Laporte Guest: Jono Bacon Download or subscribe to this show at https://twit.tv/shows/triangulation. Sponsors: ZipRecruiter.com/triangulation capterra.com/triangulation

Mikah Sargent speaks with David Weinberger, author of Everyday Chaos: Technology, Complexity, and How We're Thriving in a New World of Possibility about how AI, big data, and the internet are all revealing that the world is vastly more complex and unpredictable than we've allowed ourselves to see and how we're getting acculturated to these machines based on chaos. Buy "Everyday Chaos": https://amzn.to/2ZzxGLM Host: Mikah Sargent Guest: David Weinberger Download or subscribe to this...

Randal Munroe is the creator of the greatest comic strip on the internet: XKCD, and the author of the new book How To: Absurd Scientific Advice for Common Real-World Problems. He talks with Leo Laporte about how he got started making comic strips, the importance of not making fun of people for not knowing stuff, and the best way to generate letter pairs for kerning. Buy "How To": https://amzn.to/2ZzxGLM Host: Leo Laporte Guest: Randall Munroe Download or subscribe to this show at...

Yan Zhu, AKA bcrypt, is the Chief Security Officer at Brave. Yan joins Leo Laporte to talk about her past dropping out of high school and earning a B.S. at MIT; her work on Brave's security-focused browser and other open-source projects like HTTPS Everywhere, SecureDrop, and Privacy Badger on Firefox; DJing and creating electronic music; and more. Host: Leo Laporte Guest: Yan Zhu Download or subscribe to this show at https://twit.tv/shows/triangulation.

Bryan Walsh is the author of End Times: A Brief Guide to the End of the World. He talks with Mikah Sargent about the many, many ways Mother Earth may try to kill us all and the ways we might beat her to it. He also gives some hope for the future. Host: Mikah Sargent Guest: Bryan Walsh Download or subscribe to this show at https://twit.tv/shows/triangulation. Sponsor: capterra.com/triangulation