Terry and Jahan discuss the benefits to saunas as well as explore the biology and side topics

07:00 DNA Methylation 10:30 Machine learning 12:30 Specifics of methylation 13:50 Possible future uses of DNA Methylation 15:00 Physical activity and clocks 16:47 DHEA, metformin and decreased Horvath clock 18:30 Commercialisation of science 20:25 BPAD and Lithium 23:50 Cell and organism link 25:10 US presidents and ageing 27:23 Metacognition 31:45 Alzheimers and sleep 33:45 Alzheimers and diabetes 37:00 Alcohol, cannabis and eating for sleep 38:44 Alcohol withdrawal and sleep 44:30 Personal...

While battling multiple fronts, including night shift brain and constant interruptions - Terry and Jahan defy the odds and manage to do a podcast on the job! While it may be a bit more fragmented than usual we manage to cover the interesting topics of sleep, nasal breathing, machine learning and automating biological assays.

Jahan and Terry tackle the mammoth topic of NAD+. What is it? Why is it important and what can we possibly due to boost the levels in the body?

In this next chapter, Terry and Jahan discuss some of the contradictory literature surrounding the mechanism of AKG, the challenges to doing this kind of science, and how not to study biochemistry.

Cellular Senescence happens when both the normal cell cycle is put on pause and there is failure of the cell to die. These zombie cells have been shown to be "problematic." We discuss the pros and cons of senescence and what we can do to mitigate their deleterious effects.

What is metformin? How does it help with longevity?

Terry and Jahan discuss the challenges, benefits, and research into fasting - especially time restricted feeding.